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Paper Information

Journal:   HEPATITIS MONTHLY   FEBRUARY 2016 , Volume 16 , Number 2 ; Page(s) 0 To 0.
 
Paper: 

A PATIENT WITH PRIMARY BILIARY CIRRHOSIS ACCOMPANIED BY WILSON’S DISEASE (CASE REPORT)

 
 
Author(s):  ZHAO SU XIAN, ZHANG YU GUO, WANG RONG QI, LI WEN CONG, KONG LING BO, KONG LI, NAN YUE MIN*
 
* DEPARTMENT OF TRADITIONAL AND WESTERN MEDICAL HEPATOLOGY, THIRD HOSPITAL OF HEBEI MEDICAL UNIVERSITY, SHIJIAZHUANG, CHINA
 
Abstract: 

Introduction: Both primary biliary cirrhosis (PBC) and Wilson’s disease (WD) can cause copper retention in the liver, which is an important factor for liver cellular damage. Copper chelation may preserve liver cell function. It is challenging to distinguish WD from copper accumulation in patients with PBC. There have been few case reports of PBC co-occurrence with WD.
Case Presentation: Here we report a case of PBC with WD in a 55-year-old Chinese male. In addition to the typical pathological characteristics of PBC and a large number of copper depositions in the liver, the patient showed WD ATP7B gene mutations.
Conclusions: Co-occurrence of PBC with WD is rare, which can cause diffusely intrahepatic copper deposition. Early liver biopsy and genetic testing are necessary for the diagnosis. The combination of ursodeoxycholic acid with zinc and sodium dimercaptopropane sulfonate is effective.

 
Keyword(s): PRIMARY BILIARY CIRRHOSIS, WILSON’S DISEASE, COPPER
 
 
References: 
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APA: Copy

ZHAO, S., & ZHANG, Y., & WANG, R., & LI, W., & KONG, L., & KONG, L., & NAN, Y. (2016). A PATIENT WITH PRIMARY BILIARY CIRRHOSIS ACCOMPANIED BY WILSON’S DISEASE (CASE REPORT). HEPATITIS MONTHLY, 16(2), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=510184



Vancouver: Copy

ZHAO SU XIAN, ZHANG YU GUO, WANG RONG QI, LI WEN CONG, KONG LING BO, KONG LI, NAN YUE MIN. A PATIENT WITH PRIMARY BILIARY CIRRHOSIS ACCOMPANIED BY WILSON’S DISEASE (CASE REPORT). HEPATITIS MONTHLY. 2016 [cited 2021August01];16(2):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510184



IEEE: Copy

ZHAO, S., ZHANG, Y., WANG, R., LI, W., KONG, L., KONG, L., NAN, Y., 2016. A PATIENT WITH PRIMARY BILIARY CIRRHOSIS ACCOMPANIED BY WILSON’S DISEASE (CASE REPORT). HEPATITIS MONTHLY, [online] 16(2), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510184.



 
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