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Paper Information

Journal:   ACTA MEDICA IRANICA   2016 , Volume 54 , Number 6; Page(s) 370 To 375.
 
Paper: 

ASSOCIATION OF LIPID ACCUMULATION PRODUCT WITH CARDIO-METABOLIC RISK FACTORS IN POSTMENOPAUSAL WOMEN

 
 
Author(s):  NAMAZI SHABESTARI ALIREZA, ASADI MOJGAN*, JOUYANDEH ZAHRA, QORBANI MOSTAFA, KELISHADI ROYA
 
* OSTEOPOROSIS RESEARCH CENTER, ENDOCRINOLOGY AND METABOLISM CLINICAL SCIENCES INSTITUTE, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

The lipid accumulation product is a novel, safe and inexpensive index of central lipid over accumulation based on waist circumference and fasting concentration of circulating triglycerides. This study was designed to investigate the ability of lipid accumulation product to predict Cardio-metabolic risk factors in postmenopausal women. In this Cross-sectional study, 264 postmenopausal women by using convenience sampling method were selected from menopause clinic in Tehran. Cardio-metabolic risk factors were measured, and lipid accumulation product (waist-58×triglycerides [nmol/L]) was calculated. Optimal cut-off point of lipid accumulation product for predicting metabolic syndrome was estimated by ROC (Receiver operating characteristic) curve analysis. Metabolic syndrome was diagnosed in 41.2% of subjects. Optimal cut-off point of lipid accumulation product for predicting metabolic syndrome was 47.63 (sensitivity: 75%, specificity:77.9%). High lipid accumulation product increases risk of all Cardio-metabolic risk factors except overweight, high Total Cholesterol, high Low Density Lipoprotein Cholesterol and high Fasting Blood Sugar in postmenopausal women. Our findings show that lipid accumulation product is associated with metabolic syndrome and some Cardio-metabolic risk factors Also lipid accumulation product may have been a useful tool for predicting cardiovascular disease and metabolic syndrome risk in postmenopausal women.

 
Keyword(s): LIPID ACCUMULATION PRODUCT, MENOPAUSE, METABOLIC SYNDROME, CARDIO-METABOLIC SYNDROME
 
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