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Paper Information

Journal:   ACTA MEDICA IRANICA   2016 , Volume 54 , Number 6; Page(s) 359 To 365.
 
Paper: 

ARE MUCOSA CD4+/CD8+ T-CELLS EXPRESSIONS CORRELATED WITH THE ENDOSCOPIC APPEARANCE OF CHRONIC GASTRITIS RELATED WITH HELICOBACTER PYLORI INFECTION?

 
 
Author(s):  RATNASARI NENENG*, BAYUPURNAMA PUTUT, MADUSENO SUTANTO, INDRARTI FAHMI
 
* DEPARTMENT OF INTERNAL MEDICINE, DR. SARDJITO GENERAL HOSPITAL, GADJAH MADA UNIVERSITY, YOGYAKARTA, INDONESIA
 
Abstract: 

Local inflammatory processes in the gastric mucosa are followed by extensive immune cell infiltration, resulting in chronic active gastritis characterized by a marked infiltration of T(h)1 cytokine-producing CD4+ and CD8+T-cells Objective. To investigate the correlation between CD4+/CD8+ T-cells in gastric mucosa with endoscopic appearance in chronic gastritis with or without H.pylori infection. Prospective, cross sectional study is performed in a chronic dyspepsia population in July-November 2009 at Dr. Sardjito General Hospital Yogyakarta, Indonesia. The update Sydney system was used to analyze the gastroscopy appearance. Biopsy specimens were stained with HE-stain and IHC-stain. Data were analyzed by t-test, Mann-Whitney and Spearman correlation test. Number of 88 consecutive subjects are enrolled the study (50% male, 50% female), age 46±15 years, 25% H.pylori positive. The expression of CD4+ and CD8+ were higher in H.pylori negative subjects, but only the CD4+ was significant (P=0.011). A significant correlation was found between CD4+ and CD8+ in both subjects (r(Hp+)=0.62 and r(Hp-)=0.68, P<0.05). The expression of CD4+ and CD8+ in H.pylori positive showed a significant correlation with gastric lesions (r (CD4+)=-0.60, r(CD8+)=-0.42, P<0.05), only erosion showed a significant difference in both subjects. A positive correlation was found between CD4+ and CD8+ infiltration in both subjects with or without H.pylori infection, and a negative correlation was only found between gastric lesion with CD4+ and CD8+ infiltration in H. pylori subject.

 
Keyword(s): CD4+/CD8+ T-CELLS, H. PYLORI, GASTRIC LESION, CHRONIC GASTRITIS
 
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