Paper Information

Journal:   ACTA MEDICA IRANICA   2016 , Volume 54 , Number 5; Page(s) 308 To 312.
 
Paper: 

ASSOCIATION OF DC-SIGN AND DC-SIGNR REPEAT REGIONS WITH SUSCEPTIBILITY TO PULMONARY TUBERCULOSIS IN ZAHEDAN, SOUTHEASTERN IRAN

 
 
Author(s):  NADERI MOHAMMAD, HASHEMI MOHAMMAD*, SOROUSH NAVID, AMININIA SHADI, TAHERI MOHSEN
 
* DEPARTMENT OF CLINICAL BIOCHEMISTRY, SCHOOL OF MEDICINE, ZAHEDAN UNIVERSITY OF MEDICAL SCIENCES, ZAHEDAN, IRAN
 
Abstract: 

There are conflicting results concerning DC-SIGN and DC-SIGNR VNTR polymorphisms. The present study aimed to evaluate the possible association between DC-SIGN as well as DC-SIGNR VNTR polymorphisms and pulmonary tuberculosis (PTB) in a sample of Iranian population. This case-control study was done on 171 PTB and 161 healthy subjects. The variants were detected by polymerase chain reaction (PCR).
DC-SIGNR VNTR genotypes in cases were 12.7% for 5.5, 2.4% for 6.5, 32.7% for 7.7, 38.2% for 7.5, 5.5% for 7.6, 1.2% for /5, 0.6% for 9.6, 6.7% for 9.7 in PTB patients and 19.7% for 5.5, 2.0% for 6.5, 31.6% for 7.7, 37.5% for 7.5, 5.7% for 7.6, 0.0% for 9.5, 0.7% for 9.6, 2.6% for 9.7 in controls. The findings showed no significant association between DC-SIGNR VNTR polymorphism and PTB. All subjects in cases and controls were 7.7 genotype regarding DC-SIGN VNTR polymorphism. Our data propose that DC-SIGNR VNTR, as well as DC-SIGN VNTR, were not associated with the risk of PTB in a sample of Iranian population.

 
Keyword(s): TUBERCULOSIS, DC-SIGN, DC-SIGNR, VNTR, POLYMORPHISM
 
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