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Paper Information

Journal:   IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)   FEBRUARY-MARCH 2016 , Volume 17 , Number 6; Page(s) 435 To 439.
 
Paper: 

THE EFFECT OF L-CARNITINE AND 10 WEEKS OF AEROBIC EXERCISE ON SERUM LEVELS OF CRP IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

 
 
Author(s):  JALILI M., HEIDARIANPOUR A.*
 
* DEPARTMENT OF EXERCISE PHYSIOLOGY, FACULTY OF PHYSICAL EDUCATION AND SPORT SCIENCES, BU-ALI SINA UNIVERSITY, HAMEDAN, I.R. IRAN
 
Abstract: 

Introduction: Cardiovascular complications are considered as the main cause of morbidity and mortality in patients with diabetes mellitus. The role of increased serum concentrations of inflammatory markers, particularly C Reactive Protein (CRP), in the prediction and the pathogenesis of cardiovascular complications of type 1 diabetes has been established. The aim of the present study was to evaluate the effect of 10 weeks of L-carnitine supplementation and aerobic exercise training on serum levels of CRP in streptozotocin-induced diabetic rats. Materials and Methods: Male wistar rats (n=36), weighing 230±10 (grams) were randomly divided into 6 groups (n=6 each), including the healthy group, and the remaining (after the induction of diabetes mellitus by injection of streptozotocin), into the diabetic pre-test, diabetic control, diabetic aerobic training, diabetic oral L-carnitine treatment, and the diabetic aerobic training plus oral L-carnitine treatment groups. At the end of the interventions, blood samples were collected to determine serum levels of CRP. Data were analyzed with one-way ANOVA and Tukey's post hoc test using SPSS version 20; P values<0.05 were considered significant.
Results: Althought L-carnitine supplementation in diabetic oral L-carnitine treatment group did not significantly reduce serum levels of CRP, compared with the diabetic control group (p=0.078), it however reduced the rate of its progressive increase. Also significant reductions in CRP levels in both the aerobic training (p=0.00021) and the aerobic training plus L-carnitine supplementation groups (p<0.0001) were observed. However, the percentage changes of CRP level in the latter group was higher.
Conclusion: Results of the current study show that, aerobic training can reduce serum CRP levels in streptozotocin-induced diabetic rats, and the simultaneous use of L-carnitine supplementation, can lead to more beneficial effects.

 
Keyword(s): TYPE 1 DIABETES MELLITUS, CARDIOVASCULAR COMPLICATIONS, CRP, AEROBIC TRAINING, L-CARNITINE
 
 
References: 
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Citations: 
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APA: Copy

JALILI, M., & HEIDARIANPOUR, A. (2016). THE EFFECT OF L-CARNITINE AND 10 WEEKS OF AEROBIC EXERCISE ON SERUM LEVELS OF CRP IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 17(6), 435-439. https://www.sid.ir/en/journal/ViewPaper.aspx?id=510062



Vancouver: Copy

JALILI M., HEIDARIANPOUR A.. THE EFFECT OF L-CARNITINE AND 10 WEEKS OF AEROBIC EXERCISE ON SERUM LEVELS OF CRP IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM). 2016 [cited 2021August03];17(6):435-439. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510062



IEEE: Copy

JALILI, M., HEIDARIANPOUR, A., 2016. THE EFFECT OF L-CARNITINE AND 10 WEEKS OF AEROBIC EXERCISE ON SERUM LEVELS OF CRP IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), [online] 17(6), pp.435-439. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510062.



 
 
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