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Paper Information

Journal:   IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)   DECEMBER-JANUARY 2015 , Volume 17 , Number 5; Page(s) 409 To 415.
 
Paper: 

EVALUATING THE PREVALENCE OF ENDOCRINOPATHIES AND METABOLIC DISORDERS IN PATIENTS SUFFERING FROM SICKLE CELL ANEMIA IN KERMAN

 
 
Author(s):  GOZASHTI M.H., MOAZED V., ANVARI S.O., MASHROUTEH M.*
 
* MODELING IN HEALTH RESEARCH CENTER, INSTITUTE FOR FUTURE STUDIES IN HEALTH, KERMAN UNIVERSITY OF MEDICAL SCIENCES, KERMAN, I.R. IRAN
 
Abstract: 

Introduction: Sickle Cell Disease, Hemoglobinopathy which often requires frequent blood transfusions, is an excessive deposition of iron in the tissues, often resulting in endocrine disorders. This study aimed to determine the prevalence of endocrinopathies and metabolic disorders in patients suffering from sickle cell anemia in Kerman. Materials and Method: This cross-sectional study was conducted on 66 patients, suffering from sickle cell anemia. An information form was completed for all patients and blood samples were obtained for laboratory tests such as fasting blood sugar, serum TSH level, free T4 level, serum LH and FSH levels, serum PTH, total Ca, P and serum prolactin levels. Serum testosterone- and serum estradiol levels were checked separately, based on gender. Results were compared with normal laboratory tests, and statistically analyzed.
Results: In this study, sickle cell anemia patients, aged 14–59 were evaluated. None of the patients had diabetes mellitus. Hypothyroidism was observed in 24.2% of patients, hypoparathyroidism in 12.5%, hypogonadism in 21.2% and hyperprolactinemia in 53%.
Overall, 65.1% were found to be suffering from endocrine disorders. Statistically significant differences were seen between endocrinopathies and age.
Conclusion: Results showed age to be the important factor in endocrine disorders. Timely and appropriate treatments (including blood transfusion and receiving iron chelators) can evidently reduce iron overload in these patients and prevent its endocrine complications.

 
Keyword(s): SICKLE CELL ANEMIA, HYPOTHYROIDISM, HYPOPARATHYROIDISM, HYPOGONADISM
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

GOZASHTI, M., & MOAZED, V., & ANVARI, S., & MASHROUTEH, M. (2015). EVALUATING THE PREVALENCE OF ENDOCRINOPATHIES AND METABOLIC DISORDERS IN PATIENTS SUFFERING FROM SICKLE CELL ANEMIA IN KERMAN. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 17(5), 409-415. https://www.sid.ir/en/journal/ViewPaper.aspx?id=510058



Vancouver: Copy

GOZASHTI M.H., MOAZED V., ANVARI S.O., MASHROUTEH M.. EVALUATING THE PREVALENCE OF ENDOCRINOPATHIES AND METABOLIC DISORDERS IN PATIENTS SUFFERING FROM SICKLE CELL ANEMIA IN KERMAN. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM). 2015 [cited 2021August02];17(5):409-415. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510058



IEEE: Copy

GOZASHTI, M., MOAZED, V., ANVARI, S., MASHROUTEH, M., 2015. EVALUATING THE PREVALENCE OF ENDOCRINOPATHIES AND METABOLIC DISORDERS IN PATIENTS SUFFERING FROM SICKLE CELL ANEMIA IN KERMAN. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), [online] 17(5), pp.409-415. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510058.



 
 
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