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Paper Information

Journal:   INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR)   APRIL 2015 , Volume 9 , Number 2; Page(s) 80 To 87.
 
Paper: 

ASSOCIATION BETWEEN INTERLUKIN-6 (IL-6), INTERLUKIN-10 (IL-10) AND DEPRESSION IN PATIENTS UNDERGOING HEMATOPOIETIC STEM CELL TRANSPLANTATION

 
 
Author(s):  TAVAKOLI ARDAKANI MARIA, MEHRPOOYA MARYAM, MEHDIZADEH MAHSHID*, HAJI FATHALI ABBAS, ABDOLLAHI ALIREZA
 
* TALEGHANI BONE MARROW TRANSPLANTATION CENTER, TALEGHANI HOSPITAL AND PEDIATRIC CONGENITAL HEMATOLOGIC DISORDERS RESEARCH CENTER, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Background: The release of pro-inflammatory cytokines is responsible for the variety of behavioral, neuro-endocrine and neuro-chemical alterations in psychiatric condition. In this study we evaluate relation between depression and IL-6 and IL-10 in patients undergoing hematopoietic stem cell transplantation (HSCT). Materials and Methods: 66 patients in this cross-sectional study from July 2013 until August 2014 for HSCT interred the study and were assessed for depression using Hospital Anxiety and Depression Scale (HADS). Serum interleukin (IL) -6, (IL) -10 and high sensitive C-reactive protein (hs-CRP) were assessed on the same time. Association between these biomarkers with depression was evaluated using SPSS version 20.
Results: A total of 66 patients with the mean age of 41.18+13.92 and 41.95+12.35 years old in non depressed and depressed group respectively were enrolled in this study. Patients with depression showed significantly higher levels of serum IL-6 and the IL-6-to-IL-10 ratio compared to patients without depression (p<0.001).There was no statistically significant association between IL-10 and hs-CRP with depression in this group of the patients. Conclusions: High IL-6 level has significant association with depression in patients undergoing HSCT. In conclusion, since IL-6 can affect the outcomes after HSCT and depression was associated with increased serum IL-6 level, early identification of depression can be beneficial in these patients.

 
Keyword(s): DEPRESSION, HEMATOPOIETIC STEM CELL TRANSPLANTATION, HS-CRP, INFLAMMATORY CYTOKINES, IL-6
 
 
References: 
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Citations: 
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APA: Copy

TAVAKOLI ARDAKANI, M., & MEHRPOOYA, M., & MEHDIZADEH, M., & HAJI FATHALI, A., & ABDOLLAHI, A. (2015). ASSOCIATION BETWEEN INTERLUKIN-6 (IL-6), INTERLUKIN-10 (IL-10) AND DEPRESSION IN PATIENTS UNDERGOING HEMATOPOIETIC STEM CELL TRANSPLANTATION. INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR), 9(2), 80-87. https://www.sid.ir/en/journal/ViewPaper.aspx?id=510048



Vancouver: Copy

TAVAKOLI ARDAKANI MARIA, MEHRPOOYA MARYAM, MEHDIZADEH MAHSHID, HAJI FATHALI ABBAS, ABDOLLAHI ALIREZA. ASSOCIATION BETWEEN INTERLUKIN-6 (IL-6), INTERLUKIN-10 (IL-10) AND DEPRESSION IN PATIENTS UNDERGOING HEMATOPOIETIC STEM CELL TRANSPLANTATION. INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR). 2015 [cited 2021July25];9(2):80-87. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510048



IEEE: Copy

TAVAKOLI ARDAKANI, M., MEHRPOOYA, M., MEHDIZADEH, M., HAJI FATHALI, A., ABDOLLAHI, A., 2015. ASSOCIATION BETWEEN INTERLUKIN-6 (IL-6), INTERLUKIN-10 (IL-10) AND DEPRESSION IN PATIENTS UNDERGOING HEMATOPOIETIC STEM CELL TRANSPLANTATION. INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR), [online] 9(2), pp.80-87. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510048.



 
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