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Paper Information

Journal:   INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR)   APRIL 2015 , Volume 9 , Number 2; Page(s) 55 To 59.
 
Paper: 

HEPATIC IRON OVERLOAD AND FIBROSIS IN PATIENTS WITH BETA THALASSEMIA MAJOR AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION: A PILOT STUDY

 
 
Author(s):  GHAVAMZADEH ARDESHIR, MIRZANIA MEHRZAD*, KAMALIAN NASER, SEDIGHI NAHID, AZIMI PARISIMA
 
* CANCER RESEARCH CENTER, CANCER INSTITUTE, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, IMAM KHOMEINI HOSPITAL COMPLEX, TEHRAN, IRAN
 
Abstract: 

Currently, hematopoietic stem cell transplantation (HSCT) is the only curative option for patients with beta-thalassemia major, but liver iron overload in these patients will not decrease and hepatic fibrosis may still progress despite successful HSCT. Liver biopsy samples were taken from 14 patients (Out of 25 patients) who underwent HSCT. All patients met three criteria: negative HCV antibody, liver fibrosis in samples before HSCT and lack of regular treatment for iron overload after HSCT (Because patients did not consent to phlebotomy or they had not regular follow-up). We evaluated liver fibrosis and liver iron overload by a semi quantitative method, Perls’ Prussian blue staining, before and after HSCT. HSCT was successful in all the patients. Liver iron overload did not change after transplant (P=0.61), but hepatic fibrosis progressed after transplant (P=0.01). In patients with beta thalassemia major who previously had some degree of liver fibrosis, HSCT alone cannot reduce liver iron overload and liver fibrosis will increase. We recommend that regardless of the amount of iron overload in patients with beta thalassemia major that have shown some degree of fibrosis in their liver biopsy before transplantation, appropriate steps should be taken to reduce iron overload as soon as possible after successful transplantation.

 
Keyword(s): HEMATOPOIETIC STEM CELL TRANSPLANTATION, HEPATIC IRON OVERLOAD, PERLS’ PRUSSIAN BLUE STAINING, LIVER FIBROSIS
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

GHAVAMZADEH, A., & MIRZANIA, M., & KAMALIAN, N., & SEDIGHI, N., & AZIMI, P. (2015). HEPATIC IRON OVERLOAD AND FIBROSIS IN PATIENTS WITH BETA THALASSEMIA MAJOR AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION: A PILOT STUDY. INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR), 9(2), 55-59. https://www.sid.ir/en/journal/ViewPaper.aspx?id=510034



Vancouver: Copy

GHAVAMZADEH ARDESHIR, MIRZANIA MEHRZAD, KAMALIAN NASER, SEDIGHI NAHID, AZIMI PARISIMA. HEPATIC IRON OVERLOAD AND FIBROSIS IN PATIENTS WITH BETA THALASSEMIA MAJOR AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION: A PILOT STUDY. INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR). 2015 [cited 2021July27];9(2):55-59. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510034



IEEE: Copy

GHAVAMZADEH, A., MIRZANIA, M., KAMALIAN, N., SEDIGHI, N., AZIMI, P., 2015. HEPATIC IRON OVERLOAD AND FIBROSIS IN PATIENTS WITH BETA THALASSEMIA MAJOR AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION: A PILOT STUDY. INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR), [online] 9(2), pp.55-59. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510034.



 
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