Paper Information

Journal:   GOVARESH JOURNAL   FALL 2015 , Volume 20 , Number SUPPLEMENT; Page(s) 39 To 39.
 
Paper: 

HEREDITARY NONPOLYPOSIS COLORECTAL CANCER AND FAMILIAL COLORECTAL CANCER IN NORTHEASTHERN IRAN

 
 
Author(s):  GOSHAYESHI L.*, ESMAIEELZADEH A., BAHARI A., GHAFFARZADEGAN K., KHUIEE A.R., RAHMANI K.M., LABBAF M., AKHAVAN R.K., GANJI A., PEDRAM H., GHANAIEE O., MOKHTARIFAR A., MOZAFFARI H.
 
* INTERNAL WARD, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
 
Abstract: 

Introduction: There is a lack of data on familial aggregation of colorectal cancer (CRC) in northeast of Iran. We aimed to determine the frequency of hereditary nonpolyposis colorectal cancer (HNPCC) and familial colorectal cancer (FCC) and to determine the frequency of extracolonic cancers in these families in mashhad.
Methods: We reviewed documents of 202 patients with a pathologically confirmed diagnosis of CRC which pathology block were available in referral emamreza hospital in mashhad between 2014-2015.
We found HNPCC and FCC families based on the Amsterdam II criteria and revised Bethesda and also interviewed them for family history of CRC and extracolonic tumors. The family history was taken at least up to the second-degree relatives Results: During 2014-2015, a total of 202 CRC cases have been assesed. Clinical diagnosis of HNPCC was established in 4 (2%) probands with amesterdamII criteria and 83 (41.3%) with revised Bethesda criteria.26.7% (54) of our patients were under 45 years old.Family history of CRC was more frequently reported by early-onset (AGE<=45Y) than by late-onseT (AGE>45) patients (58.3% vs.31.1% p< 0.001).Right colon cancer was the most frequent site (30.8%) observed in patients with positive family history of colorectal cancer.
Conclusion: We found a relative high frequency of HNPCC (2%) amsterdamII among CRC cases in our region and 40.5% had revised Bethesda criteria which immunuhistochemical or molecular study to confirm HNPCC should performed. Further studies in this field and designing a specific screening and national cancer registry program for HNPCC and FCC families in this area should be conducted.

 
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