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Paper Information

Journal:   GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH   2016 , Volume 9 , Number 3; Page(s) 158 To 173.
 
Paper: 

METABOLOMIC ANALYSIS OF HUMAN CIRRHOSIS, HEPATOCELLULAR CARCINOMA, NON-ALCOHOLIC FATTY LIVER DISEASE AND NON-ALCOHOLIC STEATOHEPATITIS DISEASES (REVIEW ARTICLE)

 
 
Author(s):  SAFAEI AKRAM, AREFI OSKOUIE AFSANEH, MOHEBBI SEYED REZA, REZAEI TAVIRANI MOSTAFA, MAHBOUBI MOHAMMAD, PEYVANDI MARYAM, OKHOVATIAN FARSHAD, ZAMANIAN AZODI MONA*
 
* PROTEOMICS RESEARCH CENTER, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Metabolome analysis is used to evaluate the characteristics and interactions of low molecular weight metabolites under a specific set of conditions. In cirrhosis, hepatocellular carcinoma, non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatotic hepatitis (NASH) the liver does not function thoroughly due to long-term damage. Unfortunately the early detection of cirrhosis, HCC, NAFLD and NASH is a clinical problem and determining a sensitive, specific and predictive novel method based on biomarker discovery is an important task. On the other hand, metabolomics has been reported as a new and powerful technology in biomarker discovery and dynamic field that cause global comprehension of system biology. In this review, it has been collected a heterogeneous set of metabolomics published studies to discovery of biomarkers in researches to introduce diagnostic biomarkers for early detection and the choice of patient-specific therapies.

 
Keyword(s): CIRRHOSIS, HCC, NAFLD, NASH, METABOLOMICS
 
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