Paper Information

Journal:   GOVARESH JOURNAL   FALL 2015 , Volume 20 , Number SUPPLEMENT; Page(s) 38 To 38.
 
Paper: 

TRACE ELEMENTS STATUS OF COPPER, ALUMINUM, LEAD AND MANGANESE IN DIFFERENT TISSUES OF PATIENTS WITH COLORECTAL CANCER

 
 
Author(s):  RAZAVI S.MOHSEN, AJDARKOSH HOSSEIN, SOHRABI MASOUDREZA, NIKKHAH MEHDI, NADJAFI SHABNAM*, SOHRABI MAHMOUDREZA
 
* GASTROINTESTINAL AND LIVER DISEASE RESEARCH CENTER, IRAN UNIVERSITY OF MEDICAL SCIENCES
 
Abstract: 

Introduction: Colorectal cancers (CRC) is the third lethal cancer in many countries as Iran. Several studies in recent years have been shown that there was a link between micronutrient levels and various forms of cancer. In this study we evaluated the levels of some trace elements including copper (Cu), aluminum (Al), lead (Pb) and manganese (Mn) in patients with lower GI cancer.
Methods: From patient whom referring to Firoozgar hospital as referral hospital for evaluation their colorectal cancer between Jan 2015to May 2015, fifty patients were selected. The inclusion criteria were confirmed CRC and had not benefited from chemotherapy. The samples of blood, tumor free tissue of colon and cancerous tissue in all patients and control group were obtained. The specimens were sent to analytic chemistry lab, to assay the levels of Cu, Al, Pb and Mn. These elements were assessed by flame ionization detection (FID) method.
Results: The concentration levels of the all four elements were significantly different in patient' s tumor free tissue vs. patient's cancer tissue (p-value< 0.05). Also, the concentration levels of the all four elements except Cu were significantly different in control blood vs. patient's blood (p-value<0.05), and the levels of all four elements except Al were significantly different in healthy blood vs. patient' s cancer tissue (p-value<0.05). The concentration levels of Al and Mn were significantly different in control blood vs patient's normal tissue (p-value< 0.05). The concentration levels of Al and Pb were significantly different in patient's blood vs patient' s normal tissue (p-value<0.05). The concentration levels of Al and Cu were significantly different in patient's blood vs cancer tissue (p-value<0.05).
Conclusion: It seems that evaluation of metal elemants concentration levels can be considered for development of the useful screening tests for early diagnosis of lower GI cancer.

 
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