Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   AUGUST 2016 , Volume 19 , Number 8; Page(s) 544 To 550.
 
Paper: 

IMPORTANT FACTORS INFLUENCING SEVERITY OF COMMON VARIABLE IMMUNODEFICIENCY

 
DOI: 

0161908/AIM.005

 
Author(s):  MOKHTARI MAHISA, SHAKERI ALIREZA, MIRMINACHI BABAK, ABOLHASSANI HASSAN, YAZDANI REZA, GRIMBACHER BODO, AGHAMOHAMMADI ASGHAR*
 
* CHILDREN’S MEDICAL CENTER HOSPITAL, 62 QARIB ST., KESHAVARZ BLVD., TEHRAN 14194, IRAN
 
Abstract: 

BACKGROUND: Common variable immunodeficiency (CVID) is a primary immune deficiency with heterogeneous complications. The purpose of this study is to determine disease severity in a cohort of CVID patients based on the suggested scoring system and investigate predisposing factors which would be helpful to predict the severity of the disease.
METHODS: The study population comprised 113 CVID patients (69 males and 44 females) who were visited at Children’s Medical Center (Pediatrics Center of Excellence affiliated to Tehran University of Medical Sciences, Tehran, Iran) during the last 30 years (from 1984-2014). According to a suggested severity scoring system, patients were divided into two groups, A and B. The clinical severity of the disease in patients was assessed with severity scores including 15 unlucky complications of the disease such as numbers of past meningitis, encephalitis or pneumonias, development of bronchopulmonary pathologies, presence of lymphoproliferative disorders, autoimmunity or malignancy.
RESULTS: The mean serum IgG level was significantly higher in group B (308.6±195.9) compared to group A (177.8±151.9; P=0.03). Patients in group B had a significantly higher percentage of CD8 (P=0.003). However, they had lower percentage of CD4 lymphocytes (P=0.08), switched memory B cells (CD27+IgM-IgD-) (P<0.01) and regulatory T cells (P=0.02) than group A.
CONCLUSION: Using standard and universal scoring system and understanding of related factors can be applicable in clinical settings for prognosis assessment of CVID patients.

 
Keyword(s): AUTOIMMUNITY, COMMON VARIABLE IMMUNODEFICIENCY, SEVERITY SCORE
 
References: 
 
  pdf-File tarjomyar Yearly Visit 101
 
Latest on Blog
Enter SID Blog