Paper Information

Journal:   GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH   2016 , Volume 9 , Number 3; Page(s) 197 To 204.
 
Paper: 

SYNTHESIS AND EVALUATION OF MULTI-WALL CARBON NANOTUBE–PACLITAXEL COMPLEX AS AN ANTI-CANCER AGENT

 
 
Author(s):  GHASEMVAND FARIBA, BIAZAR ESMAEIL*, TAVAKOLIFARD SARA, KHALEDIAN MOHAMMAD, RAHMANZADEH SAEID, MOMENZADEH DARUOSH, AFROOSHEH ROSHANAK, ZARKALAMI FAEZEH, SHABANNEZHAD MARJAN, HESAMI TACKALLOU SAEED, MASSOUDI NILOFAR, HEIDARI KESHEL SAEED
 
* DEPARTMENT OF BIOMATERIALS ENGINEERING, TONEKABON BRANCH, ISLAMIC AZAD UNIVERSITY, TONEKABON, IRAN
 
Abstract: 

Aim: The aim of this study was to design multi-walled carbon nanotubes (MWCNTs) loaded with paclitaxel (PTX) anti-cancer drug and investigate its anti-cancerous efficacy of human gastric cancer.
Background: Carbon nanotubes (CNTs) represent a novel nano-materials applied in various fields such as drug delivery due to their unique chemical properties and high drug loading.
Patients and methods: In this study, multi-walled carbon nanotubes (MWCNTs) pre-functionalized covalently with a paclitaxel (PTX) as an anti-cancer drug and evaluated by different analyses including, scanning electron microscope (SEM), particle size analyzer and cellular analyses.
Results: A well conjugated of anti-cancer drug on the carbon nanotube surfaces was shown. This study demonstrates that the MWCN-PTX complex is a potentially useful system for delivery of anti-cancer drugs. The flow cytometry, CFU and MTT assay results have disclosed that MWCNT/PTXs might promote apoptosis in MKN-45 gastric adenocarcinoma cell line.
Conclusion: According to results, our simple method can be designed a candidate material for chemotherapy. It has presented a few bio-related applications including, their successful use as a nano-carriers for drug transport.

 
Keyword(s): MULTI-WALLED CARBON NANOTUBES, PACLITAXEL, STRUCTURAL INVESTIGATIONS, GASTRIC CANCER, MKN-45 CELL LINE
 
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