Paper Information

Journal:   GOVARESH JOURNAL   FALL 2015 , Volume 20 , Number SUPPLEMENT; Page(s) 36 To 36.
 
Paper: 

THE ROLE OF FECAL CALPROTECTIN AS ANON INVASIVE MARKER IN THE EVALUATION OF ULCERATIVE COLITIS ACTIVITY

 
 
Author(s):  AHADI M.*, VOSOUGHINIA H., LATIFNIA M., AMOUEIAN S., MEMAR B., HAYATBAKHSH A., MOKHTARI AMIRMAJDI E., FARZANEHFAR M.R., HOSEINI M., BEHESHTI NAMDAR A., KHOSRAVI A., SAADATNIA H.
 
* DEPARTMENT OF INTERNAL MEDICINE, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Abstract: 

Introduction: Ulcerative colitis (UC) is a chronic disease, needs long term follow up. Its follow up method is colonoscopy, which is a costly and invasive method. Fecal calprotectin (FC) is newly proposed as a predictive factor in UC patients. It is a neutrophil derived protein resistant to protease. The aim of this study was to investigate the correlation between FC and disease severity and activity in UCpatient.
Methods: This cross sectional study was approved by ethical committee of Mashhad university of medical sciences and was conducted in Qaem hospital. UC patients were carefully examined by an experienced gastroenterologist and FC level was measured quantitative ELIZA. All patients underwent colonoscopy and microscopic investigations. Data were entered SPSS version 16. And significance level was considered less than 0.05.
Results: 70 patients were enrolled the study. Their mean age was 38± 13 years. UC was recently diagnosed in 25 patients (36.2%) and mean disease duration was 5± 4.1 years. Endoscopic classification showed that 5 patients (7.1%) were in class (0), frequency of class 1, 2, 3 and 4 were 14.3%, 7.1%, 35.7% and 35.7%, respectively. Mean FC level was 132± 84
mg/g. Mean FC in mild, moderate and severe form of UC were 132± 11 mg/g, 119± 44 mg/g and 141± 78 mg/g and this difference was not statistically significant (p=0.687). No positive correlation was found between ESR and FC (r=0.172, p=0.215).
Correlation between hs-CRP and FC was not detected (r=0.252, p=0.297).
Conclusion: Our result revealed that although FC was higher in sever form of UC, there was no positive correlation between disease activity and FC.

 
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