Paper Information

Journal:   GOVARESH JOURNAL   FALL 2015 , Volume 20 , Number SUPPLEMENT; Page(s) 35 To 36.
 
Paper: 

FECAL CALPROTECTIN AND CLINICAL DISEASE ACTIVITY INDEX IN ULCERATIVE COLITIS

 
 
Author(s):  NOROUZI ALIREZA, SALAMT FAEZEH, JOSHAGHANI HAMIDREZA, MIRKARIMI HONEYSADAT, DADJOU MOHAMAD, BESHARAT SIMA*, AMIRIANI TAGHI
 
* GOLESTAN RESEARCH CENTER OF GASTROENTROLOGY AND HEPATOLOGY, LIVER AND PANCREATOBILIARY RESEARCH CENTER, DIGESTIVE DISEASE RESEARCH INSTITUTE,GOLESTAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN UNIVERSITY OF MEDICAL SCIENCES
 
Abstract: 

Introduction: It has been shown that fecal calprotectin (FC) evaluates the mucosal inflammation better than clinical indices and serum markers. The aim of this study was to assess the FC in ulcerative colitis (UC) and a control group.
Methods: The study population consists of 30 active phase UC patients, 30 remission phase and 30 healthy controls. Taking an informed consent, blood and fecal samples were taken. Fecal calprotectin was assessed by ELISA method and levels more than 200
mg/g considered abnormal. Simple Clinical Colitis Activity Index (SCCAI) was used to evaluate the disease activity. One-way ANOVA test and Pearson correlation analysis were used to analyze.
Results: The mean (±SD) of the disease activity index was 3.98±2.8, 5.95± 1.93 and 2.68± 2.52 in UC patients, active phase and remission phase, respectively (P-value=0.000). Mean (SD) FC (
mg/g) in active phase, remission phase and controls were significantly different (711.67 (227.94), 517 (328.22) and 304.02 (297.45), respectively). There was a significant correlation between FC and disease activity index (r=0.41, P-value=0.004).
Conclusion: Fecal calprotectin could be a useful tool in assessing the disease activity index in UC patients.

 
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