Paper Information

Journal:   GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH   2016 , Volume 9 , Number 3; Page(s) 225 To 230.
 
Paper: 

CLINICAL CHARACTERISTICS AND RESPONSE TO THERAPY OF AUTOIMMUNE HEPATITIS IN AN URBAN LATINO POPULATION (BRIEF REPORT)

 
 
Author(s):  ZAHIRUDDIN AYESHA, FARAHMAND ABTIN, GAGLIO PAUL, MASSOUMI HATEF*
 
* NEW YORK ASSOCIATES IN GASTROENTEROLOGY AND MONTEFIORE MEDICAL CENTER, USA
 
Abstract: 

Aim:We hypothesized that AIH outcomes might be different in our patient population that consists of a large number of Latinos.
Background: Literature has suggested that the presentation and outcome of autoimmune hepatitis can be different among different ethnicity and communities.
Patients and methods: We performed a retrospective chart review of Latino patients with AIH diagnosed between 2002-2012. Complete and partial remissions were defined as normalization of liver enzyme values, or achieving less than twice the upper limit normal (ULN), respectively.
Results: A total of 28 patients were identified. 26 (93%) were female. 13 (46%) had an acute presentation, one with type 2 AIH and 3 with ANA seronegative disease. The average pathologic stage (Ishak score) was 3.44
±1.67 (range: 0-6). Complete and partial remission was achieved in 20 (71%) and 5 (18%) patients respectively. Ten patients (38%) required maintenance prednisone either alone (2), or in combination with Azathioprine (6) or Mycophenolate Mofetil (2). Remission in the majority of patients, including 14 (50%) who were cirrhotic. Six of 14 (43%) cirrhotic patients were asymptomatic at the time of diagnosis.
Conclusion: In an urban Latino population, cirrhosis was the initial presentation of AIH in a significant percentage of patients raising concerns regarding insufficient screening for AIH in this patient population. A large number of patients required continuous prednisone to avoid relapse.

 
Keyword(s): AUTOIMMUNE HEPATITIS, HISPANIC PATIENTS, AIH
 
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