Paper Information

Journal:   GOVARESH JOURNAL   FALL 2015 , Volume 20 , Number SUPPLEMENT; Page(s) 34 To 34.
 
Paper: 

FOCAL SEGMENTALSCLEROSING GLOMERULONEPHRITIS ASSOCIATED WITH ULCERATIVE COLITIS

 
 
Author(s):  GHAVIDEL ALI*, POURI ALIASGHAR
 
* LIVER AND GASTROINTESTINAL DISEASES RESEARCH CENTRE, TABRIZ UNIVERSITY OF MEDICAL SCIENCES,TABRIZ UNIVERSITY OF MEDICAL SCIENCES
 
Abstract: 

Introduction: Inflammatory bowel disease are chronic inflammatory diseases of undetermined origin. IBD is a multifactorial polygenic disease with probable genetic heterogeneity. In this hypothesis, the disease may develop in a genetically predisposed host as a consequence of altered mucosal barrier and disregulated immune response to environmental, in particular enteric antigens, resulting in continuous immune-mediated inflammation. IBD predominantly affects the gastrointestinal system but it is associated with a large number of extraintestinal manifestations (EIMs). Some disorders parallel the activity of the bowel disease but for a number of these conditions, their courses run independently of the course of the intestinal disease.
Methods: A 30-year-old man presented 3 years earlier at this hospital when he was referred with generalized edema, hypertension, and nephrotic-range proteinuria. During the therapeutic period Kidney core; needle biopsy: was performed Glomeruli were abliteration of glomerular architecture by acellular eosinophilic material.Tubules were with no specific change. Vessels with Mild thickening of vessel wall. Interstitium with Mild chronic inflammation and fibrosis.final diagnosis Consistent with focal segmental sclerosing glomerulonephritis.He had been diagnosed with focal segmentals clerosing glomerulonephritis, serum creatinine had increased to 3 mg/dL.He was trated with 1mg/kg prednisolone and he was dischared.
Results: One of the most common types of idiopathic nephrotic syndrome in adults, is focal segmental sclerosing glomerulonephritis and usually of unknown etiology.It may be associated with infections, neoplasm, rheumatoid disorders, and drugs consumption.In the medical literature, glomerulonephritis is reported as a rare extraintestinal manifestation of inflammatory bowel disease Herein, we report a unique case of accumulating IBD during focal segmental sclerosing glomerulonephritis progression which was led to chronic kidney failure. Conclusion.

 
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