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Paper Information

Journal:   IRANIAN JOURNAL OF MICROBIOLOGY   APRIL 2016 , Volume 8 , Number 2; Page(s) 93 To 100.
 
Paper: 

EVALUATION OF ANTIBACTERIAL EFFICIENCY OF CHITOSAN AND CHITOSAN NANOPARTICLES ON CARIOGENIC STREPTOCOCCI: AN IN VITRO STUDY

 
 
Author(s):  ALIASGHARI AZAM, RABBANI KHORASGANI MOHAMMAD*, VAEZIFAR SEDIGHEH, RAHIMI FATEH, YOUNESI HABIBOLLAH, KHOROUSHI MARYAM
 
* DEPARTMENT OF BIOLOGY, FACULTY OF SCIENCES, UNIVERSITY OF ISFAHAN, IRAN
 
Abstract: 

Background and Objectives: The most prevalent and worldwide oral disease is dental caries that affects a significant proportion of the world population. There are some classical approaches for control, prevention and treatment of this pathologic condition; however, the results are still not completely successful. Therefore new methods are needed for better management of this important challenge. Chitosan is a natural and non-toxic polysaccharide with many biological applications, particularly as an antimicrobial agent. Chitosan nanoparticle is a bioactive and environment friendly material with unique physicochemical properties. The aim of the present study was to investigate the antimicrobial effect of chitosan and nano-chitosan on the most important cariogenic streptococci.
Materials and Methods: For evaluation of antimicrobial effect of chitosan and nano-chitosan against oral streptococci broth micro-dilution method was carried out for four bacterial species; Streptococcus mutans, Streptococcus sobrinus, Streptococcus sanguis and Streptococcus salivarius. Also the effect of these materials on adhesion of above bacteria was evaluated. One-way ANOVA and post hoc Tukey test were used for statistical analysis.
Results: The MICs of chitosan for S. mutans, S. sanguis, S. salivarius and S. sobrinus were 1.25, 1.25, 0.625 and 0.625 mg/mL, respectively. The MIC of chitosan nanoparticle for S. mutans, S. salivarius and S. sobrinus was 0.625 mg/mL and for S. sanguis was 0.312 mg/mL. Chitosan and chitosan nanoparticles at a concentration of 5 mg/mL also reduced biofilm formation of S. mutans up to 92.5% and 93.4%, respectively.
Conclusion: The results of this study supported the use of chitosan and chitosan nanoparticles as antimicrobial agents against cariogenic Streptococci.

 
Keyword(s): CHITOSAN, CHITOSAN NANOPARTICLES, DENTAL CARIES, ORAL STREPTOCOCCI
 
 
References: 
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Citations: 
 
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APA: Copy

ALIASGHARI, A., & RABBANI KHORASGANI, M., & VAEZIFAR, S., & RAHIMI, F., & YOUNESI, H., & KHOROUSHI, M. (2016). EVALUATION OF ANTIBACTERIAL EFFICIENCY OF CHITOSAN AND CHITOSAN NANOPARTICLES ON CARIOGENIC STREPTOCOCCI: AN IN VITRO STUDY. IRANIAN JOURNAL OF MICROBIOLOGY, 8(2), 93-100. https://www.sid.ir/en/journal/ViewPaper.aspx?id=509950



Vancouver: Copy

ALIASGHARI AZAM, RABBANI KHORASGANI MOHAMMAD, VAEZIFAR SEDIGHEH, RAHIMI FATEH, YOUNESI HABIBOLLAH, KHOROUSHI MARYAM. EVALUATION OF ANTIBACTERIAL EFFICIENCY OF CHITOSAN AND CHITOSAN NANOPARTICLES ON CARIOGENIC STREPTOCOCCI: AN IN VITRO STUDY. IRANIAN JOURNAL OF MICROBIOLOGY. 2016 [cited 2021August02];8(2):93-100. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=509950



IEEE: Copy

ALIASGHARI, A., RABBANI KHORASGANI, M., VAEZIFAR, S., RAHIMI, F., YOUNESI, H., KHOROUSHI, M., 2016. EVALUATION OF ANTIBACTERIAL EFFICIENCY OF CHITOSAN AND CHITOSAN NANOPARTICLES ON CARIOGENIC STREPTOCOCCI: AN IN VITRO STUDY. IRANIAN JOURNAL OF MICROBIOLOGY, [online] 8(2), pp.93-100. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=509950.



 
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