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Paper Information

Journal:   GOVARESH JOURNAL   FALL 2015 , Volume 20 , Number SUPPLEMENT; Page(s) 0 To 0.
 
Paper: 

A COMPARISON BETWEEN HYBRID THERAPY AND STANDARD TRIPLE THERAPY FOR HELICOBACTER PYLORI ERADICATION IN UREMIC PATIENTS: A RANDOMIZED CLINICAL TRIAL

 
 
Author(s):  MAKHLOUGH ATIEH, FAKHERI HAFEZ, HOJATI SAMANEH, HOSSEINI VAHIDEH, BARI ZOHREH*
 
* GUT AND LIVER RESEARCH CENTER,MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES
 
Abstract: 

Introduction: The prevalence of peptic ulcer disease in hemodialysis patients is more than the general population and they are also more prone to complications including upper gastrointestinal bleeding. The aim of this study was to compare the efficacy of 14 days hybrid regimen with 14 days triple therapy on Helicobacter pylori (H. pylori) eradication in hemodialysis patients.
Methods: Forty hemodialysis patients with naive H.
pylori infection were randomized to receive either hybrid regimen (Pantoprazole 40 mg BD+ Amoxicillin 500 mg BD during the first 7 days, followed by Pantoprazole 40 mg+Amoxicillin 500 mg+Clarithromycin 500mg+Tinidazole 500 mg, all twice daily, for the second 7 days) or standard triple therapy including Pantoprazole 40 mg BD, Clarithromycin 500 mg BD and Amoxicillin 500 mg BD for 14 days. H. pylori eradication was assessed by fecal H. pylori antigen test 8 weeks after the treatment.
Results: According to intention to treat analysis, the eradication rates were 87.3% (95% confidence interval= 81.4 – 93.1) and 80.9% (95% CI=74 - 87.8) in hybrid and concomitant groups, respectively (p= 0.38). Per-protocol eradication rates were 89.3% (95% CI=83.8 - 94.7) and 83.1% (95% CI=76.3 -89.8), respectively (p=0.19). The rates of severe side effects were not statistically different between the two groups (4% vs.8.7%).
Conclusion: Hybrid regimen could achieve ideal H.
pylori eradication rates with low rates of adverse effects.

 
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