Paper Information

Journal:   GOVARESH JOURNAL   FALL 2015 , Volume 20 , Number SUPPLEMENT; Page(s) 29 To 29.
 
Paper: 

EVALUATING THE EFFECTS OF CLARITHROMYCIN CONTAINING QUADRUPLE THERAPY ON HELICOBACTER PYLORI ERADICATION AFTER NITRO IMIDAZOLECONTAINING QUADRUPLE THERAPY FAILURE

 
 
Author(s):  FAKHERI HAFEZ, ALHOOEI SAMAN, BAKHSHI ZEINAB, BARI ZOHREH
 
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Abstract: 

Introduction: Several large clinical trials and meta-analyses have shown about 20% failure to eradicate Helicobacter pylori (H. pylori), necessitating investigations for second-line strategies. The aim of this study was to evaluate the effects of Clarithromycin-containing quadruple regimen afterNitroimidazole-containing quadruple therapies failure.
Methods: Thirty two patients who had failed H. pylori treatment with 10-day Omeprazole, Amoxicillin, Bismuth subcitrate and Metronidazole (OABM) regimen and 31 patients who had failed 10-day Omeprazole, Amoxicillin, Bismuth subcitrate and Furazolidone (OAMF) regimen entered the study.
They all received Omeprazole (20mg bid), Amoxicillin (1gr bid), Bismuth subcitrate (240mg bid) and Clarithromycin (500mg bid) for 10 days.
Eight weeks after therapy, H. pylori eradication was assessed by 1??C-urea breath test (UBT).
Results: totally 61 patients completed the study.
According to intention to treat (ITT) analysis, eradication rates by second-line OABC regimen were 84.37% (95% CI=71.7% – 96.9%) in OABM group and 77.41% (95% CI=62.71% – 92.11%) in OABF group (p=0.756). Per-protocol (pp) eradication rates were 87.09% (95% CI=75.2% – 98.8%) and 82.75% (95% CI=79.4% – 96%), respectively (p=0.638).
Also the cumulative eradication rates by OABC regimen were 80.9% (95% CI=71.2% – 90.6%) and 85% (95% CI=75.9% – 94%) according to ITT and PP analyses, respectively. Severe side effects were reported in 3.1% of patients.
Conclusion: Regarding ideal eradication rate (>80%) and very low adverse effects, it seems that Clarithromycin-containing quadruple therapy can be an encouraging regimen after Nitro imidazole containing regimen failure.

 
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