Paper Information

Journal:   CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES   APRIL 2016 , Volume 3 , Number 2; Page(s) 55 To 59.
 
Paper: 

MAGNESIUM SULFATE IMPROVES SPERM CHARACTERISTICS AGAINST VARICOCELE IN RAT

 
 
Author(s):  ASGHARI AHMAD*, AKBARI GHASEM, GALUSTANIAN GEGHANI
 
* DEPARTMENT OF CLINICAL SCIENCE, SCIENCE AND RESEARCH BRANCH, ISLAMIC AZAD UNIVERSITY, TEHRAN, IRAN
 
Abstract: 

Objective: The main purpose of this study was to determine the effect of magnesium sulfate on sperm characteristics in unilateral varicocele-induced male Wistar rats.
Materials and Methods: Sixty male Wistar rats were randomly divided into 6 experimental groups. The control group (1) received no medications and surgery. The Sham group (2) had not received any medications; abdominal cavity was opened but no varicocele was induced. Varicocele group (3): abdominal cavity was opened, varicocele-induced and no medications were applied. In group 4 abdominal cavity was opened, varicocele-induced and animal received magnesium sulfate (25 mg/kg) for 6 weeks. The groups 5 and 6 were similar to group 4, except animals received 50 and 100 mg/kg of magnesium sulfate, respectively. At the end of the weeks 3 and 6, the abdomen was opened, semen samples were collected from the Caudal epididymis to determine epididymis weight, sperm mortality, mobility and sperm count.
Results: According to the results, experimental unilateral varicocele significantly diminished sperm mortality, mobility and sperm count compared to control and sham group (P<0.05). Administration of magnesium sulfate as a medication dose dependently (25, 50 and 100 mg/kg) decreased sperm mortality and increased mobility and sperm count in experimental varicocele in rat compared to varicocele group at weeks 3 and 6 (P<0.05).
Conclusion: According to the results, it seems, magnesium sulfate might improve sperm characteristics during varicocele.

 
Keyword(s): MAGNESIUM SULFATE, RAT, VARICOCELE
 
References: 
 
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