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Paper Information

Journal:   PAYAVARD-SALAMAT   DECEMBER 2015-JANUARY 2016 , Volume 9 , Number 5; Page(s) 469 To 477.
 
Paper: 

STUDY OF RELATIONSHIP BETWEEN CIRCULATING ENDOTHELIAL CELL NUMBERS AND PLASMA VWF LEVELS WITH OTHER HEMATOLOGIC FINDINGS IN PATIENT WITH CHRONIC LYMPHOCYTIC LEUKEMIA

 
 
Author(s):  HEIDARPOURIAN SAMANEH, SHAHIDI MINOU*, KAZEMI AHMAD, RAZAVI MOHSEN, BASI ALI, HAYAT PARISA
 
* HEMATOLOGY AND BLOOD BANKING DEPARTMENT, SCHOOL OF ALLIED MEDICINE, CELLULAR AND MOLECULAR RESEARCH CENTER (CMRC), IRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Background and Aim: Chronic lymphocytic leukemia (CLL) is a lymphoprolifrative disorder, which is very heterogeneous in prognosis. Therefore, the analysis of the prognostic factors should be very helpful in diagnosing patients with a poor prognosis. The aim of this study was to determine the relationship between circulating Endothelial cells number with VWF levels along with the other hematological findings in CLL.
Materials and Methods: Peripheral blood samples were obtained from 30 CLL patients admitted to the hematology department of Firozgar hospital and 30 healthy subjects. The levels of CEC were measured by the presence of CD34 and VWF markers, and absence of CD45 marker, using flow cytometry. VWF levels was evaluated by ELISA.
Results: The CEC levels were significantly higher in blood of the CLL patients (0.64%), when compared to the controls (0.12%, P=0.002). The levels of plasma VWF were higher among high grade patients, when compared to controls and patients in lower grades. There was a negative correlation between CEC levels, and Hb concentration in the patients group (r=-0.47, P=0.01).
Conclusion: Although the levels of both CEC count and plasma VWF in patient with high grade CLL were increased when compared to patients with low grade, there was no significant correlation between these two parameters.

 
Keyword(s): CIRCULATING ENDOTHELIAL CELLS (CEC), VON WILLEBRAND FACTOR (VWF), CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

HEIDARPOURIAN, S., & SHAHIDI, M., & KAZEMI, A., & RAZAVI, M., & BASI, A., & HAYAT, P. (2016). STUDY OF RELATIONSHIP BETWEEN CIRCULATING ENDOTHELIAL CELL NUMBERS AND PLASMA VWF LEVELS WITH OTHER HEMATOLOGIC FINDINGS IN PATIENT WITH CHRONIC LYMPHOCYTIC LEUKEMIA. PAYAVARD-SALAMAT, 9(5), 469-477. https://www.sid.ir/en/journal/ViewPaper.aspx?id=509797



Vancouver: Copy

HEIDARPOURIAN SAMANEH, SHAHIDI MINOU, KAZEMI AHMAD, RAZAVI MOHSEN, BASI ALI, HAYAT PARISA. STUDY OF RELATIONSHIP BETWEEN CIRCULATING ENDOTHELIAL CELL NUMBERS AND PLASMA VWF LEVELS WITH OTHER HEMATOLOGIC FINDINGS IN PATIENT WITH CHRONIC LYMPHOCYTIC LEUKEMIA. PAYAVARD-SALAMAT. 2016 [cited 2021July28];9(5):469-477. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=509797



IEEE: Copy

HEIDARPOURIAN, S., SHAHIDI, M., KAZEMI, A., RAZAVI, M., BASI, A., HAYAT, P., 2016. STUDY OF RELATIONSHIP BETWEEN CIRCULATING ENDOTHELIAL CELL NUMBERS AND PLASMA VWF LEVELS WITH OTHER HEMATOLOGIC FINDINGS IN PATIENT WITH CHRONIC LYMPHOCYTIC LEUKEMIA. PAYAVARD-SALAMAT, [online] 9(5), pp.469-477. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=509797.



 
 
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