Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   PAYAVARD-SALAMAT   DECEMBER 2015-JANUARY 2016 , Volume 9 , Number 5; Page(s) 459 To 468.
 
Paper: 

EXPRESSION OF CK19 GENE IN PATIENTS WITH LUNG CANCER AND ITS COMPARISON WITH CARCINOEMBRYONIC ANTIGEN IN PERIPHERAL BLOOD

 
 
Author(s):  MOHAMADNIA ABDOLREZA, KARIMI SHIRIN, YADEGARAZARI REZA, NAJI SEYED ALIREZA, KHOSRAVI ADNAN, BAHRAMI NAGHMEH, SAIDIJAM MASSOUD*
 
* MOLECULAR MEDICINE AND GENETICS DEPARTMENT, SCHOOL OF MEDICINE, HAMADAN UNIVERSITY OF MEDICAL SCIENCES, HAMADAN, IRAN
 
Abstract: 

Background and Aim: Lung cancer is the most common cancer among men around the world. The aim of this study was to determine the expression levels of CK19 mRNA marker in the affected patients’ peripheral blood.
Materials and Methods: Thirty patients with lung cancer (NSCLC type) were compared with 30 healthy controls. After taking peripheral blood samples and extracting total RNA, cDNA was synthesized and examined by Real-time RT-PCR technique. Then, the CEA antigen was measured by ELISA.
Results: The CK19mRNA was positive in 7 out of 30 lung cancer patients.
Hence, its sensitivity was determined to be 23.3 %. The serum level of CEA antigen was positive in 11 out of 30 lung cancer patients. The mean serum level of CEA antigen markers was higher in patients than in controls; the difference was statistically significant (P<0.001). The sensitivity of this test was determined to be 36.6 %.
Conclusion: This study showed that the sensitivity of CK19 mRNA in peripheral blood was low, but it had a high specificity for the diagnosis of primary lung cancer. Also, it was found that CEA antigen could be the specific marker for the early detection of lung cancer in patients’ peripheral blood.

 
Keyword(s): LUNG CANCER, BIOMARKER, CK19 MRNA, CARCINOEMBRYONIC ANTIGEN, PERIPHERAL BLOOD
 
 
References: 
  • Not Registered.
  •  
  •  
 
Citations: 
 
+ Click to Cite.
APA: Copy

MOHAMADNIA, A., & KARIMI, S., & YADEGARAZARI, R., & NAJI, S., & KHOSRAVI, A., & BAHRAMI, N., & SAIDIJAM, M. (2016). EXPRESSION OF CK19 GENE IN PATIENTS WITH LUNG CANCER AND ITS COMPARISON WITH CARCINOEMBRYONIC ANTIGEN IN PERIPHERAL BLOOD. PAYAVARD-SALAMAT, 9(5), 459-468. https://www.sid.ir/en/journal/ViewPaper.aspx?id=509787



Vancouver: Copy

MOHAMADNIA ABDOLREZA, KARIMI SHIRIN, YADEGARAZARI REZA, NAJI SEYED ALIREZA, KHOSRAVI ADNAN, BAHRAMI NAGHMEH, SAIDIJAM MASSOUD. EXPRESSION OF CK19 GENE IN PATIENTS WITH LUNG CANCER AND ITS COMPARISON WITH CARCINOEMBRYONIC ANTIGEN IN PERIPHERAL BLOOD. PAYAVARD-SALAMAT. 2016 [cited 2021July26];9(5):459-468. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=509787



IEEE: Copy

MOHAMADNIA, A., KARIMI, S., YADEGARAZARI, R., NAJI, S., KHOSRAVI, A., BAHRAMI, N., SAIDIJAM, M., 2016. EXPRESSION OF CK19 GENE IN PATIENTS WITH LUNG CANCER AND ITS COMPARISON WITH CARCINOEMBRYONIC ANTIGEN IN PERIPHERAL BLOOD. PAYAVARD-SALAMAT, [online] 9(5), pp.459-468. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=509787.



 
 
Persian Abstract Yearly Visit 36
 
 
Latest on Blog
Enter SID Blog