Paper Information

Journal:   GOVARESH JOURNAL   FALL 2015 , Volume 20 , Number SUPPLEMENT; Page(s) 26 To 26.
 
Paper: 

COMPARISON OF TWO METHODS OF HELICOBACTER ERADICATION IN CHILDREN WITH PEPTICDISEASE

 
 
Author(s):  FARAHMAND FATEMEH*, MOHAMMADY -, KHODADAD AHMAD, NAJAFISANI MEHRI, MOTAMED -, FALLAHI GHOLAMHOSSEIN
 
* DIGESTIVE DISEASE RESERACH, PEDIATIRC UNIT, TEHRAN UNIVERSITY MEDICAL SCIENCE
 
Abstract: 

Introduction: Helicobacter pylori infection is a rather prevalent disease among Iranian children thatmight cause malnutrition, anemia or delayed growth as well as gastrointestinal problems. The purpose of this study was to compare the effect of ciprofloxacin and furazolidoneon eradicating helicobacter pylori in Iranian children in combination with amoxicillin and omeprazole.
Methods: In this cohort study, from among all the patients with gastrointestinal problems admitted to the children’s medical center with their helicobacter pylori infection confirmed through gastroscopy, rapid urease test or pathologic assessments, 66 children were randomly enrolled in the study; based on the random number table, they were divided into two groups; first, a combination regimenconsisting of ciprofloxacin, amoxicillin and omeprazole; second, a three-medication regimen consisting of amoxicillin, furazolidone and omeprazole. The effect of both medical regimens on the successful eradication of helicobacter pylori infection was assessed and compared.
Chi-square test was used for evaluating the relationship between quantitative variables. All comparisons were made at significance of P<0.05.
Results: From among all participants, 43 (65.2%) were male and 23 (34.8%) were female. The mean age was 9.69±2.91 for female patients, 9.51± 2.82 for male patients and 9.57±2.83 overall. Endoscopic tests were conducted on the patients prior to initiating their treatments, results of which showed that 66.7% of the patients had a degree of nodularity while peptic ulcer was only observed in one patient. One month after the end of the treatments, eradication of the helicobacter pylori infection was reported 87.9% (29.33) in the first group (CAO) and 60.6% (20.33) in the second group (FAO) (p=0.011).
Conclusion: It appears that a major advantage of our proposed regimen over others is lack of wide use of fluoroquinolones for treating children’s diseases.
Given FDA’s recommendation about the possibility of prescribing ciprofloxacin for infected patients with multidrug resistance, we can use the regimen proposed in this study in patients with resistance to standard treatments.

 
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