Paper Information

Journal:   GOVARESH JOURNAL   FALL 2015 , Volume 20 , Number SUPPLEMENT; Page(s) 25 To 26.
 
Paper: 

A POPULATION LEVEL SCREENING OF FIRST-DEGREE RELATIVES OF PATIENTS WITH COLORECTAL CANCERS IN TEHRAN

 
 
Author(s):  SALIMZADEH HAMIDEH*, DELAVARI ALIREZA, AMANI MOHAMMAD, BARZIN GILDA, SOHRABPOUR AMIR ALI, MALEKZADEH REZA
 
* D.D.R.I., T.U.M.S.
 
Abstract: 

Introduction: Because early-stage colon cancer is typically asymptomatic, screening especially among first-degree relatives plays a major role in the diagnosis of curable cancerous lesions, as well as the detection of precancerous lesions. Because of no available data on the incidence of colorectal pathological changes as well as cancer evidences among first-degree relatives of Iranian colorectal cancer patients, the present study aimed to determine incidence and pathological colorectal findings assessed by screening methods in first-degree relatives of patients hospitalized with colorectal cancer.
Methods: This prospective study was conducted on 400 first-degree relatives of patients who were resident in southern Tehran between 2009 and 2010.
After the initial interview and for genetic counseling, blood sample were taken. Individuals were introduced to a gastroenterologist for colonoscopy.
Results: The detection rate of polyp was 30%. The diagnosis of adenoma was confirmed in 21% that had an advanced pattern in 11% of them. The prevalence of polyp was significantly higher in men than in women (40.0 versus 19.8%, p=0.001). Also, the prevalence of adenoma was also higher in men compared with women (32.6% versus 17.1%, p=0.010). In this context, those patients with polyp was older than those without diagnosis of polyp (50.10 ±1.58 years versus 45.89± 0.84 years, p=0.012). Also, those patients with adenoma had higher mean age in comparison with those without adenoma (50.32 ±1.74 years versus 46.09± 0.83 years, p=0.017).
Conclusion: The overall prevalence of polyp and adenoma among first-degree relatives of patients with colorectal cancer is 30% and 21% respectively. Male gender and age are two indicators for these findings in first-degree relatives of patients.

 
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