Paper Information

Journal:   GOVARESH JOURNAL   FALL 2015 , Volume 20 , Number SUPPLEMENT; Page(s) 24 To 25.
 
Paper: 

PREVALENCE OF HELICOBACTER PYLORI -NEGATIVE, NON-STEROIDAL ANTI-INFLAMMATORY DRUG RELATED PEPTIC ULCER DISEASE IN PATIENTS REFERRED TO AFZALIPOUR HOSPITAL

 
 
Author(s):  SEYED MIRZAEI SEYED MAHDI, ZAHEDI MOHAMMAD JAVAD, SHAFIEI POUR SARA*
 
* INSTITUTE OF BASIC AND CLINICAL PHYSIOLOGY SCIENCES, KERMAN UNIVERSITY OF MEDICAL SCIENCES, KERMAN, IRAN
 
Abstract: 

Introduction: Although Helicobacter pylori and non-steroidal anti-inflammatory drugs (NSAIDs) compose the main causes of Peptic Ulcers Disease (PUD) but recently prevalence of Idiopathic peptic ulcer (IPU) are increasing in most parts of the world.
The aim of this study is to assess the prevalence of IPU in Kerman, the center of largest province in south-east Iran.
Methods: we included 215 patients withpeptic ulcer in our study. Combine methods rapid urease test (RUT), histology and Real time Polymerase chain reaction (PCR) was performed in endoscopic samples of peptic ulcers. NSAID use was determined by medical history. SPSS software version 16 was used for data analysis. P value<0.05 was considered as statistically significant.
Results: Of 215 consecutive peptic ulcer patients, 4 (1.8%) were H. pylori-negative and NSAID negative PUD. There were not significant differences between IPUand patients with peptic ulcer associated with H. pylori or NSAIDs in gender, age, cigarette smoking and opioid abusing.
Conclusion: our study showed that in contrast to other studies in western and some Asia countries, prevalence of IPU is low in Kerman and H. pylori infection is still the major cause of PUD.
we recommended a large and multi-center study for determine the prevalence of IPU in Iran.

 
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