Paper Information

Journal:   GOVARESH JOURNAL   FALL 2015 , Volume 20 , Number SUPPLEMENT; Page(s) 24 To 24.
 
Paper: 

PROTON PUMP INHIBITORS USE AND CHANGE IN BONE MINERAL DENSITY

 
 
Author(s):  RAZAVIZADE MOHSEN*, ARJ ABBAS, ZAMANI BATOL, YAVARI MARYAM
 
* DEPARTMENT OF GASTROENTEROLOGY, KASHAN UNIVERSITY OF MEDICAL SCIENCES, KASHAN, IRAN
 
Abstract: 

Introduction: Limited data are available reporting the effect of proton pump inhibitors (PPIs) use on change in bone mineral density (BMD).Objective: The aim of this study was to investigate the relationship between PPI use and BMD.
Methods: The current prospective analysis included 80 patients (31 males and 49 females) aged 25 to 45 years without history of hip fracture with a follow-up of at least 2 years. The study was carried out in 40 PPI users and 40 PPI nonusers. Femur and posterior-anterior spine BMD were quantified by dual-energy X-ray absorptiometry in patients who have consumed PPI at least 2 years and in nonusers PPI. The relationship between use of PPIs and BMD was tested by multivariate linear regression analysis adjusted for age, sex, BMI and several biochemical factors including serum calcium and vitamin D levels.
Results: We found that there was a significant difference between the use of PPI and femoral Tscore (-0.44
± 1.1 vs.0.19 ± 0.95, P=0.007) in exposed group compared with nonusers group. Multiple linear regression analysis revealed that there was noassociation between PPI use and femoral Z-score, lumbar spine T-score and Z-score between two studied groups. In addition, the frequency of femoral osteopenia and osteoporosis in exposed group was significantly more nonusers group (P=0.03).
Conclusion: Overall, the results of this study showed that PPI use in patients without history of hip fracture compared with control group associated with increased risk of developing osteopenia and osteoporosis in the femur bones.

 
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