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Paper Information

Journal:   GOVARESH JOURNAL   FALL 2015 , Volume 20 , Number SUPPLEMENT; Page(s) 22 To 22.
 
Paper: 

ASSESSMENT OF SERUM TUMOR MARKERS P53-AB, CRP, TGF-β, MMP-9, VEGF, E-SELECTIN, IL2R, CEA, EGFR, HER-2, FAS-LIGAND, TNF-α, SCC-AG IN ESOPHAGEAL CARCINOMA AND IT S CORRELATION WITH HISTOPATHOLOGICAL FINDINGS AND PROGNOSIS

 
 
Author(s):  MEMAR BAHRAM*, FARZADNIA MAHDI, AHADI MITRA, AMOUIAN SAKINEH, ALEDAVOOD SEYYAD AMIR
 
* SURGICAL ONCOLOGY RESEARCH CENTER, MUMS (MASHHAD UNIVERSITY OF MEDICAL SCIENCES)
 
Abstract: 

Introduction: Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive malignant tumors. Despite recent advances in diagnosis and treatment, the prognosis for patients with ESCC is poor and worse than that for patients with other digestive tract cancersClinical. Significance of Serum Markers in prognosis of esophageal cancer is controversial. The current study investigates the relation of thirteen different serum markers (P53-ab, CRP, TGF-b, MMP-9, VEGF, E-Selectin, IL2R, CEA, EGFR, Her-2, Fas-Ligand, TNF-a, SCC-Ag) in esophageal carcinoma and the correlation with histo pathologic findings and the prognostic significance.
Methods: 57 patients with esophageal carcinoma investigated retrospectively. Demographic, clinicopathalogic findings and laboratory information collected. Levels of P53-ab, CRP, TGF-
b, MMP-9, VEGF, E-Selectin, IL2R, CEA, EGFR, Her-2, Fas-Ligand, TNF-a and SCC-Ag serum markers measured by ELISA method. These Data analyzed to determine relation of levels of serum markers with histo pathologic findings, disease progression, prognosis and survival.
Results: This study consisted of 57 new esophageal cancer cases that 59.6% of them were men and mean age among these patients was 57.54
± 11.35. The most frequent pathologic finding among lesions was SCC that consisted of 93.0% of all cases. Statistical analysis showed no significant differences in any of measured parameters between (high grade/lowgrade and also dead/alive groups) groups according to grade and stage.6-month, 1-year and 2-year survival of patients were 0.627, 0.367 and 0.216 respectively.
Also, analyze of covariances showed that IL-2 and MMP-9 were independent predictor of patient' s survival (R2=1.58 and 1.47, P=0.038 and 0.028, respectively).
Conclusion: This study demonstrated significant relation between serum MMP-9 and IL-2 and survival of patients, and suggests theses serum markers to be applied as the prognosis factor in management of the patients with esophageal cancers in future.

 
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APA: Copy

MEMAR, B., & FARZADNIA, M., & AHADI, M., & AMOUIAN, S., & ALEDAVOOD, S. (2015). ASSESSMENT OF SERUM TUMOR MARKERS P53-AB, CRP, TGF-β, MMP-9, VEGF, E-SELECTIN, IL2R, CEA, EGFR, HER-2, FAS-LIGAND, TNF-α, SCC-AG IN ESOPHAGEAL CARCINOMA AND IT S CORRELATION WITH HISTOPATHOLOGICAL FINDINGS AND PROGNOSIS. GOVARESH JOURNAL, 20(SUPPLEMENT), 22-22. https://www.sid.ir/en/journal/ViewPaper.aspx?id=509709



Vancouver: Copy

MEMAR BAHRAM, FARZADNIA MAHDI, AHADI MITRA, AMOUIAN SAKINEH, ALEDAVOOD SEYYAD AMIR. ASSESSMENT OF SERUM TUMOR MARKERS P53-AB, CRP, TGF-β, MMP-9, VEGF, E-SELECTIN, IL2R, CEA, EGFR, HER-2, FAS-LIGAND, TNF-α, SCC-AG IN ESOPHAGEAL CARCINOMA AND IT S CORRELATION WITH HISTOPATHOLOGICAL FINDINGS AND PROGNOSIS. GOVARESH JOURNAL. 2015 [cited 2021July26];20(SUPPLEMENT):22-22. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=509709



IEEE: Copy

MEMAR, B., FARZADNIA, M., AHADI, M., AMOUIAN, S., ALEDAVOOD, S., 2015. ASSESSMENT OF SERUM TUMOR MARKERS P53-AB, CRP, TGF-β, MMP-9, VEGF, E-SELECTIN, IL2R, CEA, EGFR, HER-2, FAS-LIGAND, TNF-α, SCC-AG IN ESOPHAGEAL CARCINOMA AND IT S CORRELATION WITH HISTOPATHOLOGICAL FINDINGS AND PROGNOSIS. GOVARESH JOURNAL, [online] 20(SUPPLEMENT), pp.22-22. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=509709.



 
 
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