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Paper Information

Journal:   GOVARESH JOURNAL   FALL 2015 , Volume 20 , Number SUPPLEMENT; Page(s) 18 To 19.
 
Paper: 

TRACE ELEMENTS: ZINC, CHROMIUM, MANGANESE AND TIN ASSESSMENT IN UPPER GASTROINTESTINAL CANCER

 
 
Author(s):  NIKKHAH MEHDI, RAZAVI MOHSEN, KOHI ZAHRA, AJDARKOSH HOSSEIN*, NADJAFI SHABNAM, SAFARNEZHAD TAMESHKEL FAHIMEH, SOHRABI MASOUDREZA, SOHRABI MAHMOUDREZA, HOSSEINZADEH PAYAM
 
* GASTROINTESTINAL AND LIVER DISEASE RESEARCH CENTER, IRAN UNIVERSITY OF MEDICAL SCIENCES
 
Abstract: 

Introduction: Upper gastrointestinal (GI) cancers, as gastric cancer, are known cuases of death because of GI malignancies. Recently, several studies have revealed that there was a link between micronutrient levels and various forms of cancer. Thus, in this study we evaluated the levels of some trace elements including zinc (Zn), chromium (Cr), manganese (Mn) and tin (Sn) in upper GI cancer patients.
Methods: Fifty patients were selected among the referred patients to Firoozgar referral hospital for evaluation their upper GI cancer between Jan 2015 to May 2015. The inclusion criteria were confirmed gastric cancer and not receiving chemotherapy. The samples of blood, tumor free tissue and cancerous tissue of stomach in all patients were obtained. At the same time, we obtained the blood sample of fifty normal persons. The specimens were sent to analytic chemistry lab. related to Islamic Azad University of Tehran-North branch to assay the levels of Zn, Cr, Mn and Sn. The elements were assessed by flame ionization detection (FID) method.
Results: There were no significant different in concentration levels of Zn, Mn and Sn in healthy blood with their concentrations in patients' blood and tissues; also, all comparisons of Zn, Mn and Sn levels among the patients' blood, healthy tissue and cancerous tissue showed no significant statistical difference (p-value>0.05). Cr concentration levels were significantly different in healthy blood vs patient's blood (p-value<0.01). Furthermore, Cr concentration levels showed significant differences in healthy blood vs patient's cancer tissue also in patient's blood vs patient's healthy tissue (p-value<0.05).
Conclusion: According to the results, it seems that evaluation of concentration levels of Cr may be considered as etiological factor as well as an item in development of diagnostic procedure of upper GI cancer.

 
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APA: Copy

NIKKHAH, M., & RAZAVI, M., & KOHI, Z., & AJDARKOSH, H., & NADJAFI, S., & SAFARNEZHAD TAMESHKEL, F., & SOHRABI, M., & SOHRABI, M., & HOSSEINZADEH, P. (2015). TRACE ELEMENTS: ZINC, CHROMIUM, MANGANESE AND TIN ASSESSMENT IN UPPER GASTROINTESTINAL CANCER. GOVARESH JOURNAL, 20(SUPPLEMENT), 18-19. https://www.sid.ir/en/journal/ViewPaper.aspx?id=509662



Vancouver: Copy

NIKKHAH MEHDI, RAZAVI MOHSEN, KOHI ZAHRA, AJDARKOSH HOSSEIN, NADJAFI SHABNAM, SAFARNEZHAD TAMESHKEL FAHIMEH, SOHRABI MASOUDREZA, SOHRABI MAHMOUDREZA, HOSSEINZADEH PAYAM. TRACE ELEMENTS: ZINC, CHROMIUM, MANGANESE AND TIN ASSESSMENT IN UPPER GASTROINTESTINAL CANCER. GOVARESH JOURNAL. 2015 [cited 2021July30];20(SUPPLEMENT):18-19. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=509662



IEEE: Copy

NIKKHAH, M., RAZAVI, M., KOHI, Z., AJDARKOSH, H., NADJAFI, S., SAFARNEZHAD TAMESHKEL, F., SOHRABI, M., SOHRABI, M., HOSSEINZADEH, P., 2015. TRACE ELEMENTS: ZINC, CHROMIUM, MANGANESE AND TIN ASSESSMENT IN UPPER GASTROINTESTINAL CANCER. GOVARESH JOURNAL, [online] 20(SUPPLEMENT), pp.18-19. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=509662.



 
 
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