Paper Information

Journal:   GOVARESH JOURNAL   FALL 2015 , Volume 20 , Number SUPPLEMENT; Page(s) 17 To 18.
 
Paper: 

DO PATTERN OF GASTRITIS ASSOCIATE WITH GASTROESOPHAGIAL REFLUX DISEASE AMONG HP POSITIVE CHRONIC DYSPEPSIA PATIENTS

 
 
Author(s):  PANAHIAN MOHAMAD*, NOBAKHT HOSSEIN, SOHRABI MASOUDREZA, ZAMANI FARHAD, AJDARKOSH HOSSEIN, RAKHSHANI NASER
 
* GASTROINTESTINAL AND LIVER DISEASE RESEARCH CENTRE, FIROOZGAR HOSPITAL, IUMS, TEHRAN, IRAN
 
Abstract: 

Introduction: Reflux disease is a common cause of referring patients to medical care. But the association between reflux disease and gastritis pattern is controversial. To determine the association between reflux disease and gastritis patterns in patients with dyspepsia and HP infected.
Methods: Between 2010 and 2013, four hundred and seventy patients with dyspepsia and reflux disease enrolled in this study. The inclusion criteria were willing to participate; aged over 40 and having the criteria of ROME III for at least three months. Patients with history of HP eradication therapy during three months before the study; a past history of gastric surgery and gastric cancer were excluded. All of the participants underwent upper endoscopy for careful evaluation of distal esophagus and stomach. Two biopsies were taken from antrum, body and fundal areas.
Results: HP infection was detected in 367(78.1%) of the participants. The mean age of HP infected participants was 59.8±11.4 years old. Among them 241 patients (51.2%) were male. Reflux disease was seen in 273(74.4%) patients. 216 (58.9%) and 101 (27.5%) of them had NERD and GERD respectively. Corpus predominant and antral predominant gastritis were seen in 72(19.6%) and 129(35.2%) patients respectively. Antre gastritis was significantly associated with GERD (P<0.01). Although the severity of antral gastritis was associated with reflux disease (P=0.04), There was no association between atrophy of any zones of stomach with reflux disease or GERD. In regression analysis antral prominent gastritis (OR=1.92; 95%CI: 1.22- 3.12) had a significant association with GERD. The same result was observed in mild to moderate antral great curvature gastritis (OR= 1.26; 95%CI: 0.25 – 6.40 and OR= 3.0; 95%CI: 0.63 – 14.17, respectively).
Conclusion: In this study antral gastritis showed an association with GERD but corpus gastritis was found less frequently in these patients. We could suggest that the pattern of gastritis could be associated with reflux disease and GERD.

 
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