Paper Information

Journal:   GOVARESH JOURNAL   FALL 2015 , Volume 20 , Number SUPPLEMENT; Page(s) 17 To 18.
 
Paper: 

COMPLICATIONS AND SURVIVAL AFTER ORTHOTOPIC LIVER TRANSPLANTATION

 
 
Author(s):  MERAT SHAHIN, SADEGHI ANAHITA*, SOLEIMANI HAMIDREZA, NASSERI MOGHADDAM SIAVOSH
 
* DIGESTIVE DISEASE RESEARCH INSTITUTE,TEHRAN UNIVERSITY OF MEDICAL SCIENCES
 
Abstract: 

Introduction: Although improvements in technical, immunosuppressive, and intensive care management have contributed to improving the outcomes in patients receiving orthotropic liver transplants (OLT) leading to one year survival rates of over 90%, these patients are still at increased risk of long-term complications. The purpose of this study was to evaluate the short and long term complications along with survival rate among patients after OLT.
Methods: Medical records of 85 patients undergoing liver transplantation from March 1997 to May 2015 was reviewed thoroughly and the required data for survival analysis and for determining long and short term complications was extracted using a questionnaire designed according to the 2012 AASLD Practice.
Results: The most common etiologies of the initial liver failure of patients were: autoimmune hepatitis (n=23; 27%), Primary Sclerosing Cholangitis (n=18; 21%) hepatitis B virus (n=14; 16.5%).
Complications after OLT included acute rejection (n=3; 3.5%), chronic rejection (n=4; 4.7%), recurrent liver disease (n=10; 11.7%), infection (5; 5.9%) diabetes mellitus (n=5; 5.9%), osteopenia/ osteoporosis (n=19; 22%), renal failure (n=7; 8.2%) and Hodgkin’s Lymphoma (n=1). One-year, five-yearand overall survival rate were 98.8 %, 95.08% and 88.2% respectively.
Conclusion: The most common complications after OLT were metabolic bone disorders, disease recurrence and renal failure.

 
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