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Paper Information

Journal:   GOVARESH JOURNAL   FALL 2015 , Volume 20 , Number SUPPLEMENT; Page(s) 16 To 17.
 
Paper: 

THE EFFECT OF PENTOXIFYLLINE ON SERUM LEVELS OF TUMOR NECROSIS FACTOR ALPHA AND LIVER TRANSFERASES IN PATIENTS WITH NONALCOHOLIC STEATOHEPATITIS

 
 
Author(s):  BANIASADI NADIEH*, MOHAMMADI MOJGAN, SALAJEGHEH FARANAK
 
* BAM UNIVERSITY OF MEDICAL SCIENC
 
Abstract: 

Introduction: Nonalcoholic steatohepatitis (NASH) is an advanced stage of nonalcoholic fatty liver disease (NAFLD) and inflammation plays an important role in the progression of the disease.
Recently there has been much attention to pentoxifylline because it has anti-tumor necrosis alpha (TNF-alpha) effects in patients with NASH.
Some studies suggest that pentoxifylline (PTX) can improve the disease outcome.
Methods: This study was a randomized double blind placebo-controlled trial in thirty patients with NASH in the city of Kerman, south eastern Iran. All individuals gave written informed consent for enrollment in the study. Fifteen patients in the intervention group were received 400 mg pentoxifylline three times a day for six months.
Fifteen patients in the placebo group took placebo as one tablet three times a day for six months. Both the placebo and the intervention group were advised for low-calories diet/physical activities and daily exercise. Body mass index (BMI) and liver transferases including aspartate transferase (AST) and alanine transferase (ALT) were measured at time zero, three months and six months after clinical trial was started. The serum levels of TNF-alpha was measured at time zero and six months after clinical trial was started.
Results: The liver transferases were significantly decreased in both intervention and placebo groups at the end of six months clinical trial (P<0.001).
However there was no significant difference between the intervention and placebo groups with regard to the liver transferases. The serum levels of TNF-alpha was significantly reduced in the intervention group (P=0.028) at six months. Finally, Comparison of the serum levels of liver aminotransferases and cytokines between groups were insignificant.
Conclusion: It seems that decrease in the serum levels of liver aminotransferases and TNF-alfa in both groups are related to low-calorie diets and exercise rather than PTX.

 
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APA: Copy

BANIASADI, N., & MOHAMMADI, M., & SALAJEGHEH, F. (2015). THE EFFECT OF PENTOXIFYLLINE ON SERUM LEVELS OF TUMOR NECROSIS FACTOR ALPHA AND LIVER TRANSFERASES IN PATIENTS WITH NONALCOHOLIC STEATOHEPATITIS. GOVARESH JOURNAL, 20(SUPPLEMENT), 16-17. https://www.sid.ir/en/journal/ViewPaper.aspx?id=509651



Vancouver: Copy

BANIASADI NADIEH, MOHAMMADI MOJGAN, SALAJEGHEH FARANAK. THE EFFECT OF PENTOXIFYLLINE ON SERUM LEVELS OF TUMOR NECROSIS FACTOR ALPHA AND LIVER TRANSFERASES IN PATIENTS WITH NONALCOHOLIC STEATOHEPATITIS. GOVARESH JOURNAL. 2015 [cited 2021August01];20(SUPPLEMENT):16-17. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=509651



IEEE: Copy

BANIASADI, N., MOHAMMADI, M., SALAJEGHEH, F., 2015. THE EFFECT OF PENTOXIFYLLINE ON SERUM LEVELS OF TUMOR NECROSIS FACTOR ALPHA AND LIVER TRANSFERASES IN PATIENTS WITH NONALCOHOLIC STEATOHEPATITIS. GOVARESH JOURNAL, [online] 20(SUPPLEMENT), pp.16-17. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=509651.



 
 
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