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Paper Information

Journal:   JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES   2015 , Volume 7 , Number 3; Page(s) 519 To 526.
 
Paper: 

EVALUATION OF HER2/NEU GENE AMPLIFICATION (DUPLICATIONS) FREQUENCY IN PATIENTS WITH BREAST CANCER USING MLPA METHOD

 
DOI: 

10.29252/jnkums.7.3.519

 
Author(s):  POURSEIDI B., BAZRAFSHANI M.R., RASTINNIA S.*, HOSSEINI F.S.
 
* KERMAN UNIVERSITY OF MEDICAL SCIENCES, KERMAN, IRAN
 
Abstract: 

Background & Objectives: Her2/neu is a biomarker which is overexpressed in a subset of breast cancer patients who are eligible to receive treatment. Her-2 gene amplification analyzed by MLPA that is a new method to detect Her-2 status in clinical practice.
Material and Methods: 60 patients, who were operated in Afzalipour Hospital of Kerman, were enrolled in this cross-sectional study. The pathologic specimens were evaluated by MLPA method for detecting HER2 overexpression. The data were analyzed by SPSS21 software and CHI SQUARE test.
Results: Correlation between HER2 overexpression and lymph node involvement was remarkable (P value=0.0). HER2 over overexpression and size of tumor had obvious relation (P value=0.036). All the patients with HER2 overexpression were stage3 of malignancy (P value=0.0).
Conclusion: According to the results of this study it can be concluded MLPA method is a suitable method for detecting overexpression of HER2 in patients with breast cancer.

 
Keyword(s): BREAST CANCER, HER2/NEU OVEREXPRESSION, MLPA
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

POURSEIDI, B., & BAZRAFSHANI, M., & RASTINNIA, S., & HOSSEINI, F. (2015). EVALUATION OF HER2/NEU GENE AMPLIFICATION (DUPLICATIONS) FREQUENCY IN PATIENTS WITH BREAST CANCER USING MLPA METHOD. JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES, 7(3), 519-526. https://www.sid.ir/en/journal/ViewPaper.aspx?id=509635



Vancouver: Copy

POURSEIDI B., BAZRAFSHANI M.R., RASTINNIA S., HOSSEINI F.S.. EVALUATION OF HER2/NEU GENE AMPLIFICATION (DUPLICATIONS) FREQUENCY IN PATIENTS WITH BREAST CANCER USING MLPA METHOD. JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES. 2015 [cited 2021July30];7(3):519-526. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=509635



IEEE: Copy

POURSEIDI, B., BAZRAFSHANI, M., RASTINNIA, S., HOSSEINI, F., 2015. EVALUATION OF HER2/NEU GENE AMPLIFICATION (DUPLICATIONS) FREQUENCY IN PATIENTS WITH BREAST CANCER USING MLPA METHOD. JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES, [online] 7(3), pp.519-526. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=509635.



 
 
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