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Paper Information

Journal:   JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES   2015 , Volume 7 , Number 3; Page(s) 509 To 517.
 
Paper: 

IS MATERNAL NICOTINE AFFECT THE LAMININ CHAIN EXPRESSION IN THE MICE OFFSPRING KIDNEY EXTRACELLULAR MATRIX.

 
 
Author(s):  PAHANG H.*, JALALI M., NIKRAVESH M.R.
 
* DEPARTMENT OF ANATOMY, NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES, BOJNORD, IRAN
 
Abstract: 

Background & Objectives: Epidemiologic studies showed that smoking during pregnancy and lactation periods is associated with neonatal complications such as growth retardation, congenital defects. Nicotine is the most important substance in cigarettes that can pass through the placental barrier and even reaches the neonate through the milk. The purpose of this study was to evaluate the effects of maternal nicotine exposures on the offspring kidney histology and expression of laminin alpha- 5 chain in kidney extracellular matrix.
Material and Method: In this study eighteen pregnant female mice were used that divided into three groups as follow: Nicotine (3mg / kg / day) administrated intraperitoneally to pregnant mice in first group from the sixth day of gestation until delivery and similar dose injected to mice in second group from the first day of delivery until the end of lactation period. The pregnant mice in control group received same dose of normal saline. The laminin alpha-5 reaction and gene expression was assayed in the first and twenty days after delivery in offspring kidney tissue. The results were analyzed by Kruskal-Wallis and one-way ANOVA tests.
Results: Immunohistochemical (IHC) test results showed maternal nicotine receiving during gestation period reduced the intensity of laminin alpha 5 reactions significantly in glomerular matrix compared to lactation period.
Conclusion: We conclude that inhibition of Laminin? 5 expression in the embryonic kidney extracellular matrix that induced by maternal nicotine may be suppressed the nephrogenesis process during renal organogenesis.

 
Keyword(s): NICOTINE, LAMININ?5, KIDNEY, EXTRACELLULAR MATRIX
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

PAHANG, H., & JALALI, M., & NIKRAVESH, M. (2015). IS MATERNAL NICOTINE AFFECT THE LAMININ CHAIN EXPRESSION IN THE MICE OFFSPRING KIDNEY EXTRACELLULAR MATRIX.. JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES, 7(3), 509-517. https://www.sid.ir/en/journal/ViewPaper.aspx?id=509631



Vancouver: Copy

PAHANG H., JALALI M., NIKRAVESH M.R.. IS MATERNAL NICOTINE AFFECT THE LAMININ CHAIN EXPRESSION IN THE MICE OFFSPRING KIDNEY EXTRACELLULAR MATRIX.. JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES. 2015 [cited 2021August01];7(3):509-517. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=509631



IEEE: Copy

PAHANG, H., JALALI, M., NIKRAVESH, M., 2015. IS MATERNAL NICOTINE AFFECT THE LAMININ CHAIN EXPRESSION IN THE MICE OFFSPRING KIDNEY EXTRACELLULAR MATRIX.. JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES, [online] 7(3), pp.509-517. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=509631.



 
 
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