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Paper Information

Journal:   GOVARESH JOURNAL   FALL 2015 , Volume 20 , Number SUPPLEMENT; Page(s) 12 To 12.
 
Paper: 

GENDER DEPENDENT ASSOCIATION BETWEEN METABOLIC SYNDROME AND CHRONIC HEPATITIS B INFECTION

 
 
Author(s):  KATOONIZADEH AEZAM, GHOROGHI SHIMA, SHARAFKHAH MARYAM, ESLAMI LEILA, KHOSHNIA MASOUD, GHARRAVI ABDOSAMAD, MIRZAEI SAMANEH, SHAYANRAD AMANEH, POUSTCHI HOSSEIN*, MALEKZADEH REZA
 
* LIVER AND PANCREATOBILIARY DISEASES RESEARCH CENTER, DIGESTIVE DISEASES RESEARCH INSTITUTE, SHARIATI HOSPITAL, TEHRAN UNIVERSITY OF MEDICAL SCIENCES
 
Abstract: 

Introduction: Results of different studies on the association between metabolic syndrome (MS) and chronic hepatitis B infection (CHB) are conflicting.
This study aimed to assess the association between CHB, and MS using data from a large population based cohort study (Golestan Cohort Study) in Northern Iran, where the prevalence of CHB is the highest (7%) in the country.
Methods: A total of 12, 781 participants including 2249 with CHB and a random subsample of 10, 532 HBs Ag negative individuals were studied. Logistic regression model was used to assess the association between MS and CHB with adjustment for Age, ALT, PLT, alcohol intake, smoking, exercise, and socioeconomic status. MS was defined according to the ATPIII guidelines.
Results: Of the 1, 178 men participants with CHB, 201 (17.2%) had metabolic syndrome, which was significantly lower than those without MS (20.7%, P=0.007). This inverse association was remained significant after adjustments for confounding factors (OR (95%CI), 0.85 (0.79-0.99). Impaired FBS (OR (95%CI), 0.87 (0.75-1.00) and lower TG (OR (95%CI), 0.58 (0.49-0.68) levels were determinants of this inverse association. In contrast, infected women had higher prevalence of MS (41.4% vs 37.7% in none infected, P=0.02) which remained significant after adjustment for confounders (OR (95% CI); 1.23 (1.07-1.42), P<0.004). This direct association was strongly related to impaired HDL (OR (95% CI); 1.35 (1.15-1.59), P=0.001) and BP (OR (95% CI); 2.61 (2.24-3.04), P<0.001). The gender dependent association was related to BP and TG levels (P for interactions<0.001and 0.058 respectively).
Conclusion: Our results indicated a significant direct association between CHB infection and MS in women, but an inverse association between the two in men. Further longitudinal studies should be done to investigate the exact impact of HBV infection on metabolic parameters and vascular pathology.

 
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APA: Copy

KATOONIZADEH, A., & GHOROGHI, S., & SHARAFKHAH, M., & ESLAMI, L., & KHOSHNIA, M., & GHARRAVI, A., & MIRZAEI, S., & SHAYANRAD, A., & POUSTCHI, H., & MALEKZADEH, R. (2015). GENDER DEPENDENT ASSOCIATION BETWEEN METABOLIC SYNDROME AND CHRONIC HEPATITIS B INFECTION. GOVARESH JOURNAL, 20(SUPPLEMENT), 12-12. https://www.sid.ir/en/journal/ViewPaper.aspx?id=509630



Vancouver: Copy

KATOONIZADEH AEZAM, GHOROGHI SHIMA, SHARAFKHAH MARYAM, ESLAMI LEILA, KHOSHNIA MASOUD, GHARRAVI ABDOSAMAD, MIRZAEI SAMANEH, SHAYANRAD AMANEH, POUSTCHI HOSSEIN, MALEKZADEH REZA. GENDER DEPENDENT ASSOCIATION BETWEEN METABOLIC SYNDROME AND CHRONIC HEPATITIS B INFECTION. GOVARESH JOURNAL. 2015 [cited 2021August06];20(SUPPLEMENT):12-12. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=509630



IEEE: Copy

KATOONIZADEH, A., GHOROGHI, S., SHARAFKHAH, M., ESLAMI, L., KHOSHNIA, M., GHARRAVI, A., MIRZAEI, S., SHAYANRAD, A., POUSTCHI, H., MALEKZADEH, R., 2015. GENDER DEPENDENT ASSOCIATION BETWEEN METABOLIC SYNDROME AND CHRONIC HEPATITIS B INFECTION. GOVARESH JOURNAL, [online] 20(SUPPLEMENT), pp.12-12. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=509630.



 
 
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