Paper Information

Journal:   JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES   2015 , Volume 7 , Number 1; Page(s) 37 To 44.
 
Paper: 

EVALUATION OF PRO-OXIDANT-ANTIOXIDANT BALANCE (PAB) IN BLOOD STORAGE IN CONSECUTIVE WEEKS AFTER DONATION

 
DOI: 

10.29252/jnkums.7.1.37

 
Author(s):  BARZEGAR S., NADALI F.*, POURFATOLLAH A.A., ABBASPOUR A.R., FAROKHINIA S., SHIRAVAND Y.
 
* DEPARTMENT OF HEMATOLOGY, SCHOOL OF ALLIED MEDICAL SCIENCES, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Background & Objectives: Over 90 years, the blood suspension has been used to save the lives of many people. Nowadays, by the use of new techniques and blood bags, separation and storage of blood components have become possible outside the body. However, the effects of blood storage bags challenge blood transfusion. One of the side effects is oxidative stress that increases as a result of an imbalance between reactive oxygen species and antioxidants. The aim of this study was to investigate the balance of pro - oxidant - antioxidant (PAB) in consecutive weeks after blood donation.
Material and Methods: 100 blood bags produced from people's blood between 18 to 57 years old averaging 35.5 years in blood donation center of Bojnurd. The bags were kept in standard conditions for 5 weeks and after checking the health of blood in each week the needed amount were taken for examination. PAB tests were performed on samples every week.
Results: Findings showed a significant increase in oxidant - antioxidant balance in consecutive weeks after blood donation (p=0.000). It was also found that oxidants increase in the first week after the donation.
Conclusion: Oxidative stress gradually increases in blood bags as time passes after taking the bloods.

 
Keyword(s): PRO-OXIDANT – ANTIOXIDANT BALANCE, BLOOD BAGS, OXIDATIVE STRESS
 
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