Paper Information

Journal:   IRANIAN JOURNAL OF NUCLEAR MEDICINE   SUMMER 2015 , Volume 23 , Number 2 (SERIAL NUMBER 44); Page(s) 128 To 133.
 
Paper: 

18F-FDG PET/CT USEFULNESS VS TC99M-TETROFOSMIN IN THE ASSESSMENT OF MALIGNANT BRAIN GLIOMAS: REPORT OF TWO CASES

 
 
Author(s):  ALTINI CORINNA, ASABELLA ARTOR NICCOLI*, RUBINI DOMENICO, INGRAVALLO GIUSEPPE, NICOLETTI ADRIANO, RUBINI GIUSEPPE
 
* NUCLEAR MEDICINE UNIT, UNIVERSITY OF BARI “ALDO MORO”, BARI, ITALY
 
Abstract: 

Gliomas account for almost 80% of primary malignant brain tumors in adults. Magnetic Resonance imaging (MRI) is still the gold standard for diagnosis of brain tumors and brain 99mTc-tetrofosmin Single Photon Emission Computed Tomography (99mTc-tetrofosmin-SPECT) has been established as a useful tool for their evaluation. Fluorine-18–2-fluoro-2-deoxy-dglucose positron emission tomography/computed tomography (18F-FDG PET/CT) provides non-invasive information for staging, clinical assessment and prognosis of glial tumors. We report 2 cases of patients with brain lesions described on MRI suspected for malignancy, however 99mTc-tetrofosmin-SPECT that didn’t show any lesion, 18F-FDG PET/CT revealed radiotracer uptake that supported the hypothesis of malignant gliomas, confirmed later by biopsy. Our cases confirm 18FFDG PET/CT may be useful for differentiating common enhancing malignant brain tumors and is recommended when differential diagnoses are difficult to narrow using MRI and 99mTc-tetrofosmin-SPECT.18F-FDG PET/CT can be used to characterize their aggressiveness and to detect a more feasible site for a stereotaxic biopsy. It yields supplementary noninvasive information to conventional imaging useful in the clinical decision-making.

 
Keyword(s): MALIGNANT GLIOMAS, RISK STRATIFICATION, 18>/SUP>F-FDG PET/CT
 
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