Paper Information

Journal:   IRANIAN JOURNAL OF NUCLEAR MEDICINE   SUMMER 2015 , Volume 23 , Number 2 (SERIAL NUMBER 44); Page(s) 59 To 64.
 
Paper: 

EFFICACY OF RADIOSYNOVECTOMY IN THE TREATMENT OF CHRONIC KNEE SYNOVITIS: SYSTEMATIC REVIEW AND META-ANALYSIS

 
 
Author(s):  NOROUZBEIGI NASIM, ZAKAVI SEYED RASOUL, AYATI NARJES KHATOUN, FARAHATI JAMSHID, SADEGHI RAMIN, MIRFEIZI ZAHRA*
 
* RHEUMATIC DISEASES RESEARCH CENTER (RDRC), MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Abstract: 

Introduction: Knee joints are commonly involved with various inflammatory and non- inflammatory rheumatic diseases. Radiosynovectomy is being used as a local therapeutic option to alleviate pain and swelling in involved joints. The present study evaluated the effectiveness of radiosynovectomy for treatment of chronic knee synovitis.
Methods: Through a search of Medline and SCOPUS with (Radiosynovectomy OR radio-synovectomy OR "radio synovectomy" OR "radiation synovectomy" OR radiosynoviorthesis OR radio-synoviorthesis OR synoviorthesis OR "radiochemical synovectomy" OR "radioisotope synovectomy") AND (Re-188 OR Y-90 OR Sm-153 OR P-32) as key words, 9 RCTs were enrolled in the analysis.
Results: The outcomes of interest were odds ratio and risk difference of improvement in the radiosynovectomy group compared to the control group. Odds ratio and risk difference for Sm-153 plus corticosteroid subgroup was 1.959 [0.571- 6.725, P=0.285] and 14.9% [-17.1%-47%, P=0.362] respectively. The subgroup of Y-90 plus corticosteroids showed pooled odds ratio and risk difference of 2.366 [0.779-7.188, P=0.129] and 23.9% [-1.7%-49.4%, P=0.67] and in the subgroup Y-90 alone were 0.851 [0.356-2.036, P=0.717] and -2.3% [-23.3%-18.7%, P=0.829], respectively.
Conclusion: Combination of Y-90 colloid or Sm-153 with corticosteroids in radiosynovectomy have higher response rate compared to each of radioisotope or corticosteroid therapy alone.

 
Keyword(s): SYNOVECTOMY, ARTHRITIS, RADIONUCLIDE, META-ANALYSIS
 
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