Paper Information

Journal:   NOVA BIOLOGICA REPERTA   SPRING 2016 , Volume 3 , Number 1; Page(s) 1 To 14.
 
Paper: 

IMPACT OF THE INTERACTION BETWEEN MORPHINE AND α-NORADRENERGIC SYSTEM OF BASOLATERAL AMYGDALA ON ANXIETY-RELATED BEHAVIOR AND MEMORY

 
 
Author(s):  VALIZADEGAN FARHAD*, ORYAN SHAHRBANOO, ZARRINDAST MOHAMMAD REZA
 
* DEPARTMENT OF BIOLOGY, FACULTY OF SCIENCES, MAZANDARAN UNIVERSITY, BABOLSAR, IRAN
 
Abstract: 

Basolateral Amygdala is an important site of anxiety. Interactions between a-noradrenergic and opioidergic systems in Basolateral amygdale were, then, selected to investigate anxiety and memory. The elevated plus-maze was employed and the male wistar rats were tested. The site of BLA was cannulated bilaterally. Morphine (4, 5, 6 mg/kg) was injected to rats intraperitonealy, while clonidine (1, 2, 4 mg/rat) and yohimbin (0.5, 1, 2 mg/rat) were injected to BLA. Open arm time percentage (%OAT), open arm entry (%0AE) and locomotor activity were determined by this behavioral test. Retention was tested 24 hours later. Administration of morphine (6 mg/kg) increased the OAT% in anxiety test, indicating anxiolytic-like effect. Intra Basolateral amygdala infusion of clonidine (4 mg/rat) has an anxiolytic-like effect. While co-administration of clonidine (4 mg/rat) and ineffective dose of morphine (4 mg/kg) showed significant increase of OAT% in anxiety test; presenting anxiolytic response. Intra Basolateral amygdala administration of yohimbine (2 mg/rat) decreased OAT% indicating of decrease anxiety-like behavior. While Coad ministration of intra Basolateral amygdala clonidine (4 ?g/rat) and effective dose of morphine (6 mg/kg) showed a significant increase of OAT%, presenting anxiolytic response; co-administration of ineffective doses of morphine (4 mg/kg) and yohimbine (1 mg/rat) with the effective dose of clonidine (4 mg/rat) showed that yohimbine could reverse the anxiolytic-like effect of morphine and clonidine. It should be noted that there are no significant changes in locomotor activity. The results indicate that morphine creates the compromise changes in adrenergic neurons of Basolateral amygdala by changing the a-noradrenergic system on anxiety.

 
Keyword(s): NORADRENERGIC DRUGS, AMYGDALE REGION, ELEVATED PLUS MAZE, OPIOPIDERGIC, RAT
 
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