Paper Information

Journal:   JOURNAL OF DIABETES AND METABOLIC DISORDERS   OCTOBER-NOVEMBER 2015 , Volume 15 , Number 1; Page(s) 1 To 8.
 
Paper: 

THE STUDY EFFECT OF RUBUS FRUTICOSUS EXTRACT ON CUTANEOUS WOUND HEALING IN DIABETIC WISTAR RAT

 
 
Author(s):  SAYYAD ZOMORRODI MARIA, SHIRAVI ABDOLHOSSEIN*
 
* SEMNAN, DAMGHAN, SQUARE SAADI, SPRINGS ALI BOULEVARD, ISLAMIC AZAD UNIVERSITY DAMGHAN BRANCH
 
Abstract: 

Background: Diabetic foot ulcers are important topic in diabetes care. Diabetes is one of the most common metabolic diseases of endocrinology. Raspberry (Rubus fruticosus) has anti-inflammatory, anti-septic and anti-oxidant effects. The aim of present study is healing effects of raspberry extract on the regeneration process of skin wounds in control and diabetic rats.
Methods: In this study, 48 adult male rats were divided into four groups (n=12 each) including: control group (non-treated and non-diabetic rats), sham (eucerin-treated diabetic rats), experimental1 (non-treated diabetic rats) and experimental 2 (raspberry-treated diabetic rats). Diabetes was induced by 55 mg/kg Streptozotocin (STZ) in three groups of rats. A wound with 3 cm length was created on the skin of back side of animals in all groups. The experimental 1 group was treated by eucerin and experimental 2 groups were treated by raspberry extract two times in a day. Microscopic and macroscopic studies were performed on wound healing process on days of 3, 5, 7, 14 and 21.
Results: The findings showed that sham and experimental 1 group had later healing effect comparing with control group. The speed of wound healing in raspberry extract-treated rats (experimental 2 groups) had significantly increased in comparison with control group and the wound surface area has been significantly decreased in comparison with all other groups (P
£0.05).
Conclusion: It seems that topical application of raspberry extract can accelerate the wound healing in diabetic rats and materials in raspberry extract stimulate the collagen synthesis, faster wound contraction and angiogenesis.

 
Keyword(s): DIABETES, RASPBERRY, WOUND HEALING, RAT
 
References: 
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