Paper Information

Journal:   INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE   WINTER 2015 , Volume 4 , Number 1; Page(s) 40 To 45.
 
Paper: 

LACK OF ASSOCIATION BETWEEN MIRNA-146A RS2910164 AND MIRNA-499 RS3746444 GENE POLYMORPHISMS AND SUSCEPTIBILITY TO PULMONARY TUBERCULOSIS

 
 
Author(s):  NADERI MOHAMMAD, HASHEMI MOHAMMAD*, KHORGAMI PARISA, KOSHKI MALIHEH, EBRAHIMI MAHBOUBEH, AMININIA SHADI, SHARIFI MOOD BATOOL, TAHERI MOHSEN
 
* DEPARTMENT OF CLINICAL BIOCHEMISTRY, SCHOOL OF MEDICINE, ZAHEDAN UNIVERSITY OF MEDICAL SCIENCES, ZAHEDAN, IRAN
 
Abstract: 

Single-nucleotide polymorphisms (SNPs) in miRNAsmay alter its expression levels or processing and contribute to susceptibility to a wide range of diseases. Our study aimed to evaluate the possible association between miRNA-146a rs2910164 and miRNA-499 rs3746444 polymorphisms and susceptibility to pulmonary tuberculosis (PTB) in a sample of Iranian population. This case- control study was performed on 202 PTB patients and 204 healthy individuals. Genotyping was performed using tetra amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR). The results indicated that neither miRNA-499 rs3746444 nor miRNA-146a rs2910164 are associated with the risk of PTB in a sample of Iranian population. Larger studies with different ethnicities are required to validate our findings.

 
Keyword(s): TUBERCULOSIS, MICRORNA, MIRNA-146A, MIRNA-499, POLYMORPHISM
 
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