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Paper Information

Journal:   IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)   2015 , Volume 14 , Number SUPPL; Page(s) 43 To 49.
 
Paper: 

A NOVEL HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR DETERMINATION OF NYSTATIN IN PHARMACEUTICAL FORMULATIONS BY BOX–BEHNKEN STATISTICAL EXPERIMENT DESIGN

 
 
Author(s):  SHOKRANEH Farnaz, ASGHARIAN Ramin, ABDOLLAHPOUR Assem, Ramin Mehdi, Montaseri Ali, Mahboubi Arash
 
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Abstract: 
In this study a novel High Performance Liquid Chromatography for the assay of nystatin in oral and vaginal tablets were optimized and validated using Box– Behnken experimental design. The method was performed in the isocratic mode on a RP-18 column (30 ° C) using a mobile phase consisting of ammonium acetate 0. 05 M buffer/ Methanol mixture (30: 70) and a flow-rate of 1. 0 mL/min. The specificity, linearity, precision, accuracy, LOD and LOQ of the method were validated. The method was linear over the range of 5– 500 μ g/mL with an acceptable correlation coefficient (r2 = 0. 9996). The method’ s limit of detection (LOD) and quantification (LOQ) were 0. 01 and 0. 025 μ g/mL respectively. The results indicate that this validated method can be used as an alternative method for assay of nystatin.
 
Keyword(s): Nystatin,High performance liquid chromatography,Box–,Behnken experimental design
 
 
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Citations: 
 
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APA: Copy

SHOKRANEH, F., & ASGHARIAN, R., & ABDOLLAHPOUR, A., & Ramin, M., & MONTASERI, A., & MAHBOUBI, A. (2015). A NOVEL HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR DETERMINATION OF NYSTATIN IN PHARMACEUTICAL FORMULATIONS BY BOX–BEHNKEN STATISTICAL EXPERIMENT DESIGN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 14(SUPPL), 43-49. https://www.sid.ir/en/journal/ViewPaper.aspx?id=509039



Vancouver: Copy

SHOKRANEH Farnaz, ASGHARIAN RAMIN, ABDOLLAHPOUR ASSEM, Ramin Mehdi, MONTASERI ALI, MAHBOUBI ARASH. A NOVEL HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR DETERMINATION OF NYSTATIN IN PHARMACEUTICAL FORMULATIONS BY BOX–BEHNKEN STATISTICAL EXPERIMENT DESIGN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR). 2015 [cited 2021August06];14(SUPPL):43-49. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=509039



IEEE: Copy

SHOKRANEH, F., ASGHARIAN, R., ABDOLLAHPOUR, A., Ramin, M., MONTASERI, A., MAHBOUBI, A., 2015. A NOVEL HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR DETERMINATION OF NYSTATIN IN PHARMACEUTICAL FORMULATIONS BY BOX–BEHNKEN STATISTICAL EXPERIMENT DESIGN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), [online] 14(SUPPL), pp.43-49. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=509039.



 
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