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Paper Information

Journal:   PAJOUHESH DAR PEZESHKI   2015 , Volume 39 , Number 2; Page(s) 92 To 98.
 
Paper: 

RELATION OF MULTIPLE SCLEROSIS AND INTERFERON-BETA CONSUMPTION WITH EXPRESSION OF THIOREDOXIN TRX 1

 
 
Author(s):  MAHMOUDIAN ELHAM, KHALILNEZHAD AHAD, MAHMOODI FATEMEH, GHARAGOZLI KUROSH, AMANI DAVAR*
 
* DEPARTMENT OF IMMUNOLOGY, SCHOOL OF MEDICINE, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN 1985717443, IRAN
 
Abstract: 

Background: Regarding the increasing incidence of multiple sclerosis (MS), importance of biomarkers, and also the probable changes in expression of Trx1 gene in this disease, herein we investigated mRNA expression level of Trx1 gene in peripheral blood leukocytes of patients with MS, receiving no medications and those receiving interferon beta, relative to healthy individuals.
Methods: Six healthy subjects, as control, and 12 patients with multiple sclerosis, divided into two groups of patients without medications (n=6) and interferon-beta receiving patients (n=6), were included in the study. The numbers of Trx1 mRNA transcripts in two groups of the patients was measured by SYBR green real-time PCR technique, and compared relative to those of healthy individuals.
Results: The mRNA expression of Trx1 in patients without medications was about 1.98 folds higher relative to the healthy controls. However, this difference was not statistically significant (p>0.05). Also, the mRNA expression of Trx1 in interferon-beta receiving patients exhibited an insignificant increase (p>0.05) relative to that of healthy controls and patients without medications (3.28 and 1.66 folds, respectively).
Conclusion: According to our results, the expression of Trx1 gene seems to be a suitable index for MS especially in the patients receiving interferon beta. However, more remains to be elucidated in support of this hypothesis through large-sample size studies. Also, the possible effect of other medications followed by MS patients including immunosuppressive drugs is suggested to receive attention in future investigations.

 
Keyword(s): ANTI-OXIDANTS., MULTIPLE SCLEROSIS, OXIDANTS, REDOX SYSTEM, THIOREDOXIN
 
 
References: 
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Click to Cite.
APA: Copy

MAHMOUDIAN, E., & KHALILNEZHAD, A., & MAHMOODI, F., & GHARAGOZLI, K., & AMANI, D. (2015). RELATION OF MULTIPLE SCLEROSIS AND INTERFERON-BETA CONSUMPTION WITH EXPRESSION OF THIOREDOXIN TRX 1. PAJOUHESH DAR PEZESHKI, 39(2), 92-98. https://www.sid.ir/en/journal/ViewPaper.aspx?id=509032



Vancouver: Copy

MAHMOUDIAN ELHAM, KHALILNEZHAD AHAD, MAHMOODI FATEMEH, GHARAGOZLI KUROSH, AMANI DAVAR. RELATION OF MULTIPLE SCLEROSIS AND INTERFERON-BETA CONSUMPTION WITH EXPRESSION OF THIOREDOXIN TRX 1. PAJOUHESH DAR PEZESHKI. 2015 [cited 2021May13];39(2):92-98. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=509032



IEEE: Copy

MAHMOUDIAN, E., KHALILNEZHAD, A., MAHMOODI, F., GHARAGOZLI, K., AMANI, D., 2015. RELATION OF MULTIPLE SCLEROSIS AND INTERFERON-BETA CONSUMPTION WITH EXPRESSION OF THIOREDOXIN TRX 1. PAJOUHESH DAR PEZESHKI, [online] 39(2), pp.92-98. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=509032.



 
 
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