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Paper Information

Journal:   IRANIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS   January-February 2016 , Volume 31 , Number 6 (74); Page(s) 1096 To 1103.
 
Paper: 

THE INHIBITORY SYNERGISTIC EFFECTS OF VERAPAMIL AND SATUREJA HORTENSIS ESSENTIAL OIL ON CHOLINERGIC CONTRACTION OF RAT ILEUM

 
 
Author(s):  HEJAZIAN S.H.*, SAFARI F., BAMERI M.
 
* DEPARTMENT OF PHYSIOLOGY/HERBAL MEDICINE RESEARCH CENTER, SCHOOL OF MEDICINE, SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, YAZD, IRAN
 
Abstract: 

Verapamil inhibits the cytosolic calcium content by blocking both activated and inactivated T-type calcium. Regarding the spasmolytic effect of materials caused by blockage of calcium channels and due to the inhibitory effect of Satureja hortensis L. on ileum smooth muscle contraction. The present study was designed to find out the synergistic effects of calcium blocker verapamil and Satureja essential oil on inhibition of cholinergic contraction in male rat’s ileum. In this study, by using an oscillographic device, the effects of different concentration of Satureja essential oil and verapamil were examined on isotonic contraction of ileum induced by acetylcholine10-4M. Our results showed that both verapamil and Satureja essential oils inhibited acetylcholine-induced contraction of ileum. In addition, their ineffective doses had synergistic spasmolytic effects, which were statistically significant (p<0.05).

 
Keyword(s): VERAPAMIL, SATUREJA HORTENSIS L., ESSENTIAL OIL, SPASMOLYTHIC, ACETYLCHOLINE, ILEUM, SMOOTH MUSCLE
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

HEJAZIAN, S., & SAFARI, F., & BAMERI, M. (2016). THE INHIBITORY SYNERGISTIC EFFECTS OF VERAPAMIL AND SATUREJA HORTENSIS ESSENTIAL OIL ON CHOLINERGIC CONTRACTION OF RAT ILEUM. IRANIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS, 31(6 (74)), 1096-1103. https://www.sid.ir/en/journal/ViewPaper.aspx?id=509030



Vancouver: Copy

HEJAZIAN S.H., SAFARI F., BAMERI M.. THE INHIBITORY SYNERGISTIC EFFECTS OF VERAPAMIL AND SATUREJA HORTENSIS ESSENTIAL OIL ON CHOLINERGIC CONTRACTION OF RAT ILEUM. IRANIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS. 2016 [cited 2021July23];31(6 (74)):1096-1103. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=509030



IEEE: Copy

HEJAZIAN, S., SAFARI, F., BAMERI, M., 2016. THE INHIBITORY SYNERGISTIC EFFECTS OF VERAPAMIL AND SATUREJA HORTENSIS ESSENTIAL OIL ON CHOLINERGIC CONTRACTION OF RAT ILEUM. IRANIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS, [online] 31(6 (74)), pp.1096-1103. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=509030.



 
 
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