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Paper Information

Journal:   PAJOUHESH DAR PEZESHKI   2015 , Volume 39 , Number 2; Page(s) 55 To 59.
 
Paper: 

EVALUATION OF CD4+CD25+FOXP3+REGULATORY T-CELLS INCREASE IN TUMOR ENVIRONMENT OF INVASIVE INTRADUCTAL BREASTCARCINOMA AND CONTROL GROUP

 
 
Author(s):  OFOGHI MAHYA, MESDAGHI MEHRNAZ, KHALILNEZHAD AHAD, TAHERIPANAH ROBABEH, AMANI DAVAR*
 
* DEPARTMENT OF IMMUNOLOGY, SCHOOL OF MEDICINE, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN 1985717443, IRAN
 
Abstract: 

Background: It seems that the population of regulatory T-cells increases in many malignancies leading to suppression of effector immune responses and thereby leads to progression of the disease. We aimed to assess infiltration of the regulatory T-cells into tumor environment in women with breast carcinoma.
Methods: In a control-case study, 9 malignant tumor tissues from invasive intraductal breast carcinoma (case) and 8 benign breast tissues from healthy women (control) were mechanically and enzymatically processed. The prepared cell suspension was then subjected to staining of cell surface markers CD4 and CD25, and the extracellular marker FOXP3, and was finally analyzed by flow cytometry.
Results: Population of regulatory T-cells in malignant tumor tissues showed significant increase compared to the control (p<0.001). A weak positive correlation was observed between size of the tumors and the infiltration of regulatory T-cells. Also, there was a moderate negative correlation between age of individuals and the number of regulatory T-cells in both malignant and benign breast tissues.
Conclusions: Increased regulatory T-cells population in invasive intraductal breast tumor environment may be the major cause of immunosuppression contributing to the tumor progression. However, further studies with larger sample size are suggested to clarify this hypothesis.

 
Keyword(s): FLOW CYTOMETRY, INVASIVE INTRADUCTAL BREAST CARCINOMA, REGULATORY T-CELLS
 
 
References: 
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Click to Cite.
APA: Copy

OFOGHI, M., & MESDAGHI, M., & KHALILNEZHAD, A., & TAHERIPANAH, R., & AMANI, D. (2015). EVALUATION OF CD4+CD25+FOXP3+REGULATORY T-CELLS INCREASE IN TUMOR ENVIRONMENT OF INVASIVE INTRADUCTAL BREASTCARCINOMA AND CONTROL GROUP. PAJOUHESH DAR PEZESHKI, 39(2), 55-59. https://www.sid.ir/en/journal/ViewPaper.aspx?id=508995



Vancouver: Copy

OFOGHI MAHYA, MESDAGHI MEHRNAZ, KHALILNEZHAD AHAD, TAHERIPANAH ROBABEH, AMANI DAVAR. EVALUATION OF CD4+CD25+FOXP3+REGULATORY T-CELLS INCREASE IN TUMOR ENVIRONMENT OF INVASIVE INTRADUCTAL BREASTCARCINOMA AND CONTROL GROUP. PAJOUHESH DAR PEZESHKI. 2015 [cited 2021May08];39(2):55-59. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=508995



IEEE: Copy

OFOGHI, M., MESDAGHI, M., KHALILNEZHAD, A., TAHERIPANAH, R., AMANI, D., 2015. EVALUATION OF CD4+CD25+FOXP3+REGULATORY T-CELLS INCREASE IN TUMOR ENVIRONMENT OF INVASIVE INTRADUCTAL BREASTCARCINOMA AND CONTROL GROUP. PAJOUHESH DAR PEZESHKI, [online] 39(2), pp.55-59. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=508995.



 
 
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