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Paper Information

Journal:   PAJOUHESH DAR PEZESHKI   2015 , Volume 39 , Number 1; Page(s) 20 To 25.
 
Paper: 

C29T (PRO10LEU) POLYMORPHISM OF TRANSFORMING GROWTH FACTOR⓵ (TGF-⓵) GENE AND UNEXPLAINED INFERTILITY IN IRAN

 
 
Author(s):  MARHEMATI FARNAZ, MOHSENI MEYBODI ANAHITA, TAHERIPANAH ROBABEH, AMANI DAVAR*
 
* DEPARTMENT OF GYNECOLOGY AND OBSTETRICS, REPRODUCTIVE HEALTH RESEARCH CENTER, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Background: The increasing incidence of infertility is alarming. About %30-10 of infertilities are classified as unexplained infertility (UI), which is not an absolute clinical condition. TGF-b1 is multifunctional cytokine and produced mainly by T regulatory (Treg) lymphocytes. This cytokine plays an important role in physiology of normal pregnancy. The association of single nucleotide Polymorphisms (SNPs) of TGF-b1 gene with many immunologic diseases has been reported. In this study, the association of TGF-b1 C29T (Pro10Leu) gene polymorphism with unexplained infertility was investigated in Iranian UI patients.
Materials and Methods: In this case-control study blood samples were collected from 177 UI patients (142 male and 35 female) and 336 controls (232 male and 104 female) with no history of infertility. DNA was extracted by salting out method. Analysis of the TGF-
b1 gene polymorphism C29T (Pro10Leu) was performed by PCR and automated sequencing method.
Results: The genotype distributions and allele frequencies of TGF-
b1 gene C29T (Pro10Leu) polymorphism were not statistically significant between different categories of UI patients and control group (p>0.05).
Conclusion: The results of this study showed, C29T (Pro10Leu) polymorphism of TGF-
b1 gene may not be associated with unexplained infertility and further studies are necessary to clarify the association of TGF-b1 polymorphisms and susceptibility to unexplained infertility.

 
Keyword(s): INFERTILITY, POLYMORPHISM, CYTOKINE, TGF-⓵ GENE, UNEXPLAINED INFERTILITY
 
 
References: 
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Click to Cite.
APA: Copy

MARHEMATI, F., & MOHSENI MEYBODI, A., & TAHERIPANAH, R., & AMANI, D. (2015). C29T (PRO10LEU) POLYMORPHISM OF TRANSFORMING GROWTH FACTOR⓵ (TGF-⓵) GENE AND UNEXPLAINED INFERTILITY IN IRAN. PAJOUHESH DAR PEZESHKI, 39(1), 20-25. https://www.sid.ir/en/journal/ViewPaper.aspx?id=508909



Vancouver: Copy

MARHEMATI FARNAZ, MOHSENI MEYBODI ANAHITA, TAHERIPANAH ROBABEH, AMANI DAVAR. C29T (PRO10LEU) POLYMORPHISM OF TRANSFORMING GROWTH FACTOR⓵ (TGF-⓵) GENE AND UNEXPLAINED INFERTILITY IN IRAN. PAJOUHESH DAR PEZESHKI. 2015 [cited 2021May07];39(1):20-25. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=508909



IEEE: Copy

MARHEMATI, F., MOHSENI MEYBODI, A., TAHERIPANAH, R., AMANI, D., 2015. C29T (PRO10LEU) POLYMORPHISM OF TRANSFORMING GROWTH FACTOR⓵ (TGF-⓵) GENE AND UNEXPLAINED INFERTILITY IN IRAN. PAJOUHESH DAR PEZESHKI, [online] 39(1), pp.20-25. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=508909.



 
 
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