Paper Information

Journal:   RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)   FEBRUARY-MARCH 2016 , Volume 20 , Number 6 (108); Page(s) 308 To 314.
 
Paper: 

PROTECTIVE EFFECT OF BROCCOLI SPROUTS POWDER AGAINST METABOLIC FRUCTOSE-INDUCED METABOLIC DISORDERS IN RATS

 
 
Author(s):  ABD MISHANI MAHSHID, BAHADORAN ZAHRA, EJTAHED HANIEH SADAT, MIRMIRAN PARVIN, AZIZI FEREIDOUN
 
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Abstract: 

Background and Aim: In this study, we aimed to investigate whether a diet rich in high-sulforaphane broccoli sprouts powder (BSP) could attenuate metabolic abnormalities induced by high-fructose corn syrup (HFCS).
Materials and Methods: Forty-eight male wistar rats with similar average body weight (253±23g) were randomly allocated into four groups: Baseline control, control (C) (normal diet), fructose (F) (normal diet + water containing 30% fructose), and fructose + BSP (F+B) (diet with 5% BSP + water containing 30% fructose), and followed for 8 weeks. Biochemical measurements including fasting serum triglyceride levels, total cholesterol, HDL-C, alkaline phosphatase, gamma-glutamyl transferase, alanine aminotransferase, and aspartate aminotransferase were assessed at baseline, and the fourth and eighth weeks.
Results: The mean change of body weight was 31.5%, 31.4% and 18.3% in the C, F, and F+B groups, respectively; the mean weight gain of group F+B was lower than those of the other groups (p=0.009). A significant increasing trend was observed in serum total cholesterol, triglycerides and LDL-C levels in group F during the intervention (p<0.05). Serum alkaline phosphatase and gamma-glutamyl transferase also showed a significant increasing trend in group F (p<0.05). After 8-weeks of intervention, in group F+B, LDL-C was significantly lower (p=0.001) and HDL-C was significantly higher (p=0.048) than the other groups.
Conclusion: High-sulforaphane broccoli sprouts could have favorable effects against metabolic disorders-induced by a high fructose diet.

 
Keyword(s): BROCCOLI SPROUT, SULFORAPHANE, HIGH, FRUCTOSE CORN SYRUP, METABOLIC DISORDERS
 
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