Paper Information

Journal:   JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES   JANUARY-FEBRUARY 2016 , Volume 22 , Number 6; Page(s) 1099 To 1104.
 
Paper: 

CORRELATION OF SOX2 AND NOTCH SIGNALING IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA

 
 
Author(s):  NAJAFI MARYAM, FARSHCHIAN MOEIN, ROSTAMI ESMAIEL, KARAMI MADANI GHOLAMREZA, RAD ABOLFAZL*
 
* SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, SABZEVAR
 
Abstract: 

Background and purposes: Esophageal Squamous cell carcinoma (ESCC) is ranked as the sixth cause of cancer-related death. However there are chemotherapy, radiotherapy and surgical as standard treatment, for this cancer the survival rate is lower. Therefore, clarification of molecular pathways are needed for diagnosis, prevention and treatment. In this study we aimed to evaluate the ectopic expression of SOX2 and its correlation with Notch signaling pathways.
Materials and Methods: Using lentiviral SOX2, we did transduction in KYSE 30 cells and over-expressed SOX2. Then, we confirmed the overexpression by Real time PCR. Also the correlation of SOX2 overexpression with Notch signaling factors was assessed by Real time PCR.
Results: The over-expression of SOX2 in KYSE 30 give rise to up-regulation of Notch signaling factors.
Conclusion: Our data showed, the overexpression of SOX2 causes overexpression of HEY1 and HEY2 which maintain stemness in ESCC. These concepts will require deeper studies to use as biomarker for ESCC.

 
Keyword(s): ESCC, SOX2, HEY1, HEY2
 
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