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Paper Information

Journal:   RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)   JANUARY-FEBRUARY 2016 , Volume 22 , Number 140; Page(s) 108 To 117.
 
Paper: 

A REVIEW ON THE DNA METHYLATION AND ITS ROLE IN THYROID TUMOR GENESIS

 
 
Author(s):  FAAM BITA, EMAM FATEMEH, GHAFFARI MOHAMAD ALI*, AZIZI FEREIDOUN
 
* CELLULAR AND MOLECULAR RESEARCH CENTER, DEPARTMENT OF BIOCHEMISTRY, SCHOOL OF MEDICAL, JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES, AHVAZ, IRAN
 
Abstract: 

Epigenetic modification is one of the effective factors in tumorigenesis. Epigenetic processes, especially aberrant DNA methylation, play important role in thyroid cancer, and many tumor suppressor genes including PTEN, RASSF1A and TIMP3 are aberrantly methylated and silenced in thyroid cancer. Because of the specified pattern of DNA methylation in various tumor cells, it is suggested that these genes take part in a specific pathway. In addition to tumor suppressor genes, aberrant methylation in thyroid-specific genes such as those for sodium/iodide symporter and thyroid-stimulating hormone receptor is also common in thyroid tumorigenesis and progression. On the other hand, changes in these genes expression is one of the main cause for the failure of clinical radio-iodine treatment in subjects with thyroid cancer. Considering the importance of this issue, the present study intends to investigate the DNA methylation patterns of related genes in thyroid tumorogenesis.

 
Keyword(s): EPIGENETIC, DNA METHYLATION, THYROID CANCER, TUMOR SUPPRESSOR GENES, THYROID SPECIFIC GENES
 
 
References: 
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Click to Cite.
APA: Copy

FAAM, B., & EMAM, F., & GHAFFARI, M., & AZIZI, F. (2016). A REVIEW ON THE DNA METHYLATION AND ITS ROLE IN THYROID TUMOR GENESIS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 22(140), 108-117. https://www.sid.ir/en/journal/ViewPaper.aspx?id=508623



Vancouver: Copy

FAAM BITA, EMAM FATEMEH, GHAFFARI MOHAMAD ALI, AZIZI FEREIDOUN. A REVIEW ON THE DNA METHYLATION AND ITS ROLE IN THYROID TUMOR GENESIS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES). 2016 [cited 2021May11];22(140):108-117. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=508623



IEEE: Copy

FAAM, B., EMAM, F., GHAFFARI, M., AZIZI, F., 2016. A REVIEW ON THE DNA METHYLATION AND ITS ROLE IN THYROID TUMOR GENESIS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), [online] 22(140), pp.108-117. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=508623.



 
 
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