Paper Information

Journal:   RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)   DECEMBER 2015-JANUARY 2016 , Volume 22 , Number 139; Page(s) 27 To 34.
 
Paper: 

COMPARISON THE EFFECT OF CALCIUM SULFATE AND FERRIC SULFATE IN CONTROLLING LIVER BLEEDING: AN ANIMAL MODEL STUDY

 
 
Author(s):  NOURI SAEED, SHARIF MOHAMMAD REZA*, JAMALI BARDIA, PANAHI YUNES
 
* TRAUMA RESEARCH CENTER, KASHAN UNIVERSITY OF MEDICAL SCIENCES, KASHAN, IRAN
 
Abstract: 

Background: The control of parenchymal hemorrhage especially in liver parenchyma, despite surgical science progresses, is still one of the challenges surgeons face saving the patients’ lives and there is a research challenge between the researchers in this field to introduce a more effective method. This study aimed to compare the hemostatic effect of calcium sulfate and ferric sulfate on controlling the bleeding from liver parenchymal tissue.
Methods: In this animal model study 60 male wistar rats were used. A length of two cm and a depth of half a cm incision was made on each mouse’s liver and the hemostasis time was measured using calcium sulfate and ferric sulfate different concentrations (15%, 25%, and 50%). Finally, the obtained data were entered into SPSS software and analyzed using Kruskal-wallis test, Mann – Whitney, Kolmogorov – Smirnov and also Wilcoxon signed ranks test.
Results: In all groups we had complete hemostasis. The hemostasis time of calcium sulfate concentration groups was significantly less than that of the ferric sulfate group (p<0.01).
Conclusion: Calcium sulfate and ferric sulfate can control liver bleeding and both are effective hemostatic agents in controlling liver parenchymal tissue hemorrhage in an animal model.

 
Keyword(s): HEMOSTASIS, CALCIUM SULFATE, FERRIC SULFATE, LIVER
 
References: 
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